Quercetin Composition Synergistic Zika Virus Inhibition
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Solution Overview
Problem
Current treatments are ineffective for Flaviviridae family viruses, including Zika virus, which can cause severe symptoms and maternal-fetal transmission, leading to fetal loss and microcephaly, with no known effective treatment available.
Innovation Solution
A method involving the administration of a quercetin-containing composition, combined with vitamin B3, vitamin C, and a folate compound, or isoquercetin, to inhibit Zika virus intracellular and infectious virus production, potentially preventing microcephaly and related neurological disorders, and can be used with anti-viral drugs to reduce side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional therapies are used for Flaviviridae family viruses, then treatment is available, but the treatment is ineffective
Solution Approach 1:
The patent combines quercetin with vitamin B3, vitamin C, and folate compounds to create a synergistic therapeutic composition. This combination approach merges multiple bioactive components that work together to inhibit viral replication more effectively than conventional single-agent therapies, directly addressing the ineffectiveness of existing treatments for Flaviviridae viruses.
Solution Approach 2:
The invention changes the chemical and biological parameters of the treatment by using quercetin and its derivatives (such as isoquercetin) combined with specific vitamins and folate compounds. This parameter change in the therapeutic approach enables effective inhibition of Zika virus and other Flaviviridae family viruses where conventional therapies fail.
2Reliability
If anti-viral drugs are used at higher doses to improve efficacy, then virus inhibition is enhanced, but side effects increase
Solution Approach 1:
The patent merges quercetin with vitamin B3, vitamin C, and folate compounds to create a synergistic composition that enhances viral inhibition at lower doses. This combination allows the therapeutic to achieve effective virus suppression without the high doses that cause severe side effects, as the components work together to amplify the anti-viral effect.
Solution Approach 2:
The vitamin and folate components act as intermediaries that enhance the activity of quercetin, allowing for reduced dosing of the primary anti-viral agent while maintaining or improving efficacy. This intermediary approach reduces the burden on the body and minimizes side effects associated with high-dose monotherapy.
Data Source
AI summary
A method for treating Zika virus infection with a composition containing quercetin or isoquercetin, together with one or more of vitamin B3, vitamin C, and a folate compound is described. Methods of preventing microcephaly and treating and preventing infections of other Flavivridae viruses are also described.