Quinic Acid Skin and Scalp Composition for Redness Prevention
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Solution Overview
Problem
Existing cosmetic formulations fail to effectively prevent or slow the appearance of unesthetic signs associated with skin and scalp inflammation, particularly on sensitive and reactive skin, due to imbalances in the cutaneous microbiota and inflammatory responses triggered by factors like temperature changes, chemicals, and pollutants.
Innovation Solution
A composition comprising polysubstituted quinic acid derivatives, primarily from burdock root extracts, combined with organic solvents and water, is applied topically to reduce inflammation by regulating the skin's microbiota and inhibiting inflammatory cytokines, using a method of aeroponic cultivation and specific compound ratios.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing cosmetic formulations are used, then the skin receives basic care, but they fail to effectively prevent or slow the appearance of unesthetic signs associated with inflammation
Solution Approach 1:
The patent uses a composite active composition containing multiple polysubstituted quinic acid derivatives (caffeoylquinic acid, chlorogenic acid, cryptochlorogenic acid, isocryptochlorogenic acid) in specific proportions. This composite approach synergistically addresses microbiota imbalance and inflammatory responses, overcoming the limitation of single-compound formulations and effectively preventing inflammation signs on sensitive skin.
2Object-affected harmful factors
If the skin is exposed to external stresses like temperature changes and chemicals, then it performs its barrier function, but unesthetic inflammatory signs such as redness appear particularly on sensitive skin
Solution Approach 1:
The active composition containing polysubstituted quinic acid derivatives is applied before or during exposure to external stresses to preemptively counteract inflammatory responses. The derivatives stabilize the skin microbiota and inhibit pro-inflammatory cytokine production in advance, preventing the appearance of redness and other unesthetic signs rather than treating them after they occur.
Solution Approach 2:
The patent transforms the skin's inflammatory response to external stresses from a harmful effect into a controlled physiological response. By modulating the immune system's reaction through polysubstituted quinic acid derivatives, the formulation allows the skin to maintain its protective barrier function while converting excessive inflammatory reactions (redness, irritation) into balanced, aesthetically pleasing responses.
3Reliability
If polysubstituted quinic acid derivatives are used at high concentrations, then anti-inflammatory effect is enhanced, but formulation stability and skin compatibility may be compromised
Solution Approach 1:
The patent optimizes the concentration parameters of each polysubstituted quinic acid derivative within specific ranges: caffeoylquinic acid (0.01-10% w/w), chlorogenic acid (0.01-5% w/w), cryptochlorogenic acid (0.01-5% w/w), and isocryptochlorogenic acid (0.01-5% w/w). These parameter optimizations ensure maximum anti-inflammatory efficacy while maintaining formulation stability and skin compatibility, avoiding the pitfalls of both under-dosing and over-concentration.
Data Source
AI summary
A composition that prevents or slows the appearance of blemishes associated with inflammation of the skin and/or scalp, includes per 100% by mass: a) 60.0%-75.0% by mass of an organic solvent chosen from 1,2-propanediol, 1,3-propanediol, 1,4-butanediol, 1,3-butanediol, 1,2-butanediol, 2-methyl-2,4-pentanediol, 1,6-hexanediol, 1,8-octanediol, or a blend of the above compounds; b) 0.1%-2.0% by mass of a composition including a mass quantity x1, expressed as mass equivalent of 1-O-(2-caffeyol)maloyl-3,5-O-dicaffeoylquinic acid, greater than or equal to 200 mg/g of a compound of general formula (I):in which Q1 and Q3-Q5 independently of each other represent the hydroxyl radical or a salt thereof or a radical selected among the caffeoyl, maloyl, caffeoyl maloyl and maloyl caffeoyl radicals; at least one of Q1 and Q3-Q5 represents neither the —OH radical nor a salt thereof; and c) 20.0%-35.0% by mass water.