Quinoline Derivative Control Agent for Mesostigmata Mite Resistance
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Solution Overview
Problem
Current control agents are ineffective against Mesostigmata mites that parasitize or suck blood from homoiotherms, with recent decreases in drug sensitivity necessitating a novel and highly effective agent.
Innovation Solution
Compounds such as azoxystrobin, picoxystrobin, and their acid addition salts are used as active ingredients in a Mesostigmata mite control agent, providing effective control against mites like red mites and northern fowl mites by direct application or to their habitats.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional control agents are used against Mesostigmata mites, then initial control effect is achieved, but drug sensitivity decreases over time rendering them ineffective
Solution Approach 1:
The patent applies parameter changes by switching from conventional control agents to quinoline derivatives with specific chemical structures (formula 1). This chemical parameter change restores control effectiveness against Mesostigmata mites that have developed resistance to previous agents, thereby resolving the contradiction between initial effectiveness and long-term sensitivity maintenance
2Reliability
If novel control agents are developed to overcome resistance, then control effectiveness is improved, but safety requirements become more stringent
Solution Approach 1:
The patent applies local quality by designing quinoline derivatives with specific substituent patterns (R1, R2, R3 groups in formula 1) that target Mesostigmata mite physiology specifically. This localized chemical design achieves high control effectiveness while maintaining safety by exploiting unique biological characteristics of the target mites rather than broad-spectrum toxicity
Data Source
AI summary
A control agent comprising, as an active ingredient, a specific quinoline derivative compound such as 8-fluoro-2,3-dimethyl-6-(1,1-dimethylethyl)-4-(methylcarbonyl)oxyquinoline, azoxystrobin, picoxystrobin, pyraclostrobin, kresoxim-methyl, trifloxystrobin, metominostrobin, orysastrobin, famoxadone, fluoxastrobin, pyribencarb, cyazofamid, amisulbrom, flutolanil, mepronil, isofetamid, fluopyram, carboxin, thifluzamide, fluxapyroxad, furametpyr, penflufen, penthiopyrad, boscalid, diflumetorim, fluazinam, ferimzone, fenpyroximate, or an acid addition salt of any of these compounds shows an excellent controlling effect on Mesostigmata mites.