Racemic Beta-Hydroxybutyrate Mixed Salt-Acid Compositions
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Transitioning into and maintaining a ketogenic state is challenging due to the difficulty in depleting glucose stores, accompanied by uncomfortable symptoms like hypoglycemia, electrolyte imbalances, and the need for strict dietary ratios, making it hard to sustain ketosis.
Innovation Solution
Racemic R,S-beta-hydroxybutyrate mixed salt-acid compositions that include a 50:50 ratio of R- and S-beta-hydroxybutyrate salts and acids, providing a rapid and sustained increase in ketone bodies, which can be administered to induce and maintain ketosis with reduced side effects and improved absorption.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If endogenous ketosis is induced through fasting and exercise to deplete glucose stores, then ketone body levels increase, but the process is physically demanding, emotionally challenging, and accompanied by uncomfortable symptoms like hypoglycemia and electrolyte imbalances
Solution Approach 1:
The patent introduces exogenous ketone bodies (beta-hydroxybutyrate salts and acids) as an intermediary substance that mediates the transition to ketosis. Instead of forcing the body to deplete glucose stores through fasting and exercise, the ketone bodies are supplied directly, bypassing the harmful intermediate states of hypoglycemia and electrolyte imbalance while achieving the desired ketotic state.
Solution Approach 2:
The patent applies preliminary action by providing ketone bodies before the body would naturally need them through fasting. The exogenous ketone supplementation prepares the body for ketosis in advance, eliminating the need to endure the uncomfortable transition period and allowing immediate entry into the ketogenic state without the harmful side effects.
2Duration of action of stationary object
If strict dietary ratios of carbohydrates and protein to fats are maintained to sustain ketosis, then ketone production continues, but the dietary restrictions make it difficult to maintain and require constant monitoring
Solution Approach 1:
The patent enables self-service by providing ketone bodies directly through supplementation, which sustains ketosis independently of dietary compliance. The body's own ketone production mechanisms are bypassed, and ketosis is maintained through the exogenous supply of ketone bodies, eliminating the need for strict dietary ratios and constant monitoring of carbohydrate and protein intake.
3Duration of action of moving object
If glucose stores are depleted through fasting and exercise to enter ketosis, then the body shifts to fat metabolism, but the transition period lasts 2-3 weeks with symptoms like lethargy and light-headedness
Solution Approach 1:
The patent converts the harm of slow natural transition into benefit by using exogenous ketone supplementation. Instead of accepting the 2-3 week transition period with harmful symptoms like lethargy and light-headedness, the patent provides ketone bodies directly, transforming the problematic natural process into a rapid, symptom-free transition that delivers the same metabolic benefits immediately.
Data Source
AI summary
Ketogenic compositions include a racemic mixture of R- and S-beta-hydroxybutyric acids and a racemic mixture of R- and S-beta-hydroxybutyrate salts. The compositions contain the R-enantiomer to elevate ketone bodies and increase the rate at which ketosis is achieved and yet contain an equivalent amount of the S-enantiomer to provide alternative benefits. The R- and S-beta-hydroxybutyric acids are more rapidly absorbed and utilized by the body than salts or esters, enhance taste, and reduce the need to include citric acid or other edible acids. The R- and S-beta-hydroxybutyrate salts are more slowly absorbed and utilized by the body and can provide one or more electrolytes. The ketogenic composition may contain a dietetically or pharmaceutically acceptable carrier and a racemic mixture of R- and S-beta-hydroxybutyrate salts and acids. The composition contains less than 100% by molar equivalents of total R,S-beta-hydroxybutyrate salts and more than 0% by molar equivalents of R,S-beta-hydroxybutyric acids.