Biologic Disruptor Radial Rotor Eliminates Axial Bearing

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Solution Overview

Problem

Existing disruptors for biologic substances face challenges in efficiently disrupting cells and tissues while minimizing axial load on the rotor, which often requires axial bearings, and they either complicate assembly or do not maintain the integrity of the biologic material.

Innovation Solution

A disruptor with a coaxial loading and collecting chamber design, featuring a radially projecting blade rotor and a fixed disrupting grid with micro-cells, which allows for radial flow and eliminates the need for an axial bearing by distributing load radially, maintaining the integrity of biologic samples.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If a rotor with axial blades is used to disrupt biologic substances, then disruption efficiency is improved, but axial load on the rotor increases requiring axial bearings

Engineering Contradiction:

Improvedisruption efficiencyVSAvoidbearing requirement

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

The patent inverts the conventional disruption mechanism by replacing axial blade rotation with radial blade rotation. The rotor blades extend radially from the rotation axis perpendicular to the rotation axis, creating disruption through radial motion rather than axial motion. This inversion eliminates the need for axial bearings while maintaining effective disruption of biologic substances.

Inventive Principle:

Principle #13The other way round (Inversion)

Solution Approach 2:

The patent changes the dimension of blade projection from axial (parallel to rotation axis) to radial (perpendicular to rotation axis). The blades are arranged in a plane perpendicular to the rotation axis, rotating in a plane parallel to the rotation axis. This dimensional change allows the rotor to generate sufficient disruption force without requiring axial bearing support.

Inventive Principle:

Principle #17Another dimension (Dimensionality change)

2Reliability

If chemical reagents are used to maintain sample integrity, then sample characteristics are preserved, but additional processing steps are required

Engineering Contradiction:

Improvesample integrityVSAvoidprocessing steps

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent replaces chemical methods with a mechanically optimized disruption system. The radial blade rotor working against an axial disrupting grid creates mechanical disruption that preserves sample integrity without requiring chemical reagents. The specific geometric arrangement of blades and grid cells provides controlled mechanical action that maintains biologic material characteristics.

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The disrupting grid with axial cells performs the function of both structural support and sample integrity maintenance. The grid cells are configured to guide and control the disruption process inherently, eliminating the need for external chemical agents to preserve sample characteristics during processing.

Inventive Principle:

Principle #25Self-service

3Ease of manufacture

If a single chamber design is used, then device construction is simplified, but separation of loading and collecting functions is reduced

Engineering Contradiction:

Improveconstruction simplicityVSAvoidloading and collecting efficiency

Core Design Contradiction:

Ease of manufactureVSProductivity

Solution Approach 1:

The patent segments the internal chamber into functionally distinct zones: a loading chamber for introducing biologic substances and a collecting chamber for receiving disrupted material. The axial disrupting grid serves as both a structural element and a flow separator, guiding material from the loading zone through the disruption area into the collecting zone. This segmentation improves operational efficiency while maintaining construction simplicity.

Inventive Principle:

Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The disruptor efficiently processes biologic substances with radial flow, maintaining sample integrity and simplifying assembly, suitable for medical, veterinary, and cosmetic applications without the need for chemical reagents.

Implementation Method 1

radial flow, from the central loading chamber for biologic substances to be disrupted, to the collecting chamber of disrupted biologic substances

Methodology Applied

Scientific EffectRadial flow:

Implementation Method 2

with knives or other cutters which cut the material into fragments, with rotary knives inside vertical containers

Methodology Applied

Scientific EffectMechanical cutting: Abrasion

Data Source

PatentEP3409369B1Disrupting device of biologic substances

Publication Date: 2023.06.14 CTSV SRL

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AI summary

A disrupting device (1) of biologic substances is described, comprising at least one external hollow body (10) defining at least one internal chamber; at least one fixed disrupting grid (20) housed inside the internal chamber to define at least one loading chamber of biologic substances to be disrupted and at least one collecting chamber of disrupted biologic substances; at least one rotor (30) rotating inside the internal chamber to take the biologic substances in contact with the fixed disrupting grid (20) and to cooperate with the fixed disrupting grid (20) to allow a disruption and a passage from the loading chamber to the collecting chamber of the disrupted biologic substances through the fixed disrupting grid (20).