Radioactive Glass Microspheres with Cavities for Liver Embolization
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Solution Overview
Problem
Current radioactive microspheres for liver cancer embolization face challenges with high density leading to poor distribution and deposition in liver blood vessels, and low nuclide loading capacity, which limits their therapeutic effectiveness.
Innovation Solution
Radioactive glass microspheres with cavities are created by adding a foaming agent to the glass matrix, which decomposes at high temperature to form bubbles, reducing density to 1.4-2.3 g/cm3 and increasing nuclide loading capacity to 15-40 wt%, allowing for better distribution and deposition in liver blood vessels.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If glass microspheres with high density are used to increase nuclide loading capacity, then the radiation dose increases, but the distribution and deposition effects in liver blood vessels deteriorate
Solution Approach 1:
The patent changes the density parameter of glass microspheres from conventional high density (3.6 g/cm³) to a controlled low density range (1.4-2.3 g/cm³) by adjusting glass composition and incorporating voids, achieving both adequate nuclide loading capacity and improved distribution in liver blood vessels
Solution Approach 2:
The patent creates composite glass microspheres combining multiple oxides (silica, boron oxide, aluminum oxide, calcium oxide, magnesium oxide) with controlled proportions to achieve optimal density and nuclide loading capacity simultaneously, forming a material that balances both requirements
2Reliability
If glass microspheres with low density are used to improve distribution in blood vessels, then the deposition effects improve, but the nuclide loading capacity decreases
Solution Approach 1:
The patent optimizes the density parameter to a specific low density range (1.4-2.3 g/cm³) rather than simply reducing density, enabling adequate nuclide loading (15-40 wt%) while maintaining good distribution and deposition characteristics in liver blood vessels
3Quantity of substance
If conventional glass microspheres are used, then the nuclide loading rate is high, but the sedimentation velocity is too high causing poor distribution
Solution Approach 1:
The patent changes the density parameter of glass microspheres from conventional high density to a controlled low density range (1.4-2.3 g/cm³), which significantly reduces sedimentation velocity while maintaining adequate nuclide loading capacity through optimized glass composition and void incorporation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The microspheres achieve improved distribution and deposition in liver blood vessels, enhancing the therapeutic effect by maintaining a higher radiation dose and stability, effectively targeting tumor cells while minimizing damage to normal hepatic cells.
Implementation Method 1
adding a foaming agent to the glass matrix, which decomposes at high temperature to form bubbles
Implementation Method 2
decomposes at high temperature to form bubbles, reducing density to 1.4-2.3 g/cm3
Implementation Method 3
Radionuclide emitting rays loaded by the microspheres generally include a beta-ray and have an action distance within a few millimeters to tens of millimeters
Implementation Method 4
kill surrounding carcinoma cells through radiation
Implementation Method 5
The microspheres can be highly concentrated and retained in micro-blood vessels of the hepatoma carcinoma cells, so as to embolize nourishing blood vessels of tumors
Data Source
AI summary
The present invention provides radioactive glass microspheres for embolization and a preparation method and an application thereof. A nuclide oxide and a foaming agent are added into a glass matrix, blended and uniformly mixed for making the foaming agent decomposed and vaporized at a high temperature to generate bubbles, so as to prepare the radioactive glass microspheres for embolization with cavities. The radioactive glass microspheres for embolization have a density of 1.4-2.3 g/cm3, a nuclide loading rate of 15-40 wt % and a higher and more stable radiation dose, can achieve better distribution and deposition effects in liver blood vessels after injection, and can achieve a better therapeutic effect for hepatocellular carcinoma (HCC).