Radioactive Microsphere Suspension With Low Non-Spherical Ratio
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Solution Overview
Problem
Existing radioactive microspheres used in cancer treatment cause adverse reactions and have limited efficacy, particularly for larger tumors, due to their high non-spherical ratio and particle size distribution.
Innovation Solution
A suspension of radioactive microspheres with controlled non-spherical ratio of 5% or less and average particle size of 25 μm to 40 μm, made from resin microspheres like crosslinked polystyrene or polydivinylbenzene, loaded with radionuclides such as yttrium [90Y], is developed to improve distribution and therapeutic efficacy while reducing adverse reactions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing radioactive microspheres are used, then tumor treatment is provided, but adverse reactions occur and therapeutic efficacy is limited
Solution Approach 1:
The patent changes the physical parameters of microspheres by controlling particle size (20-60 μm with 25-40 μm average) and non-spherical ratio (≤5%). These parameter modifications improve microsphere distribution within tumors, enhancing therapeutic efficacy while reducing adverse reactions such as fever and liver impairment
2Volume of moving object
If microspheres with larger particle size are used, then distribution in tumor is improved, but particle size uniformity becomes difficult to control
Solution Approach 1:
The patent optimizes the particle size parameter to 20-60 μm range with an average of 25-40 μm, and controls the non-spherical ratio to ≤5%. This parameter optimization achieves improved tumor distribution while maintaining manufacturing precision through controlled synthesis conditions
3Ease of manufacture
If high non-spherical ratio microspheres are used, then production is easier, but therapeutic effect is reduced
Solution Approach 1:
The patent sets the non-spherical ratio parameter to ≤5% (comparing to conventional higher ratios), which requires more precise manufacturing control but significantly improves therapeutic effect by enhancing microsphere distribution density within tumors, particularly in deeper tumor regions
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The controlled non-spherical ratio and particle size enhance tumor distribution density, improving therapeutic efficacy and safety by reducing adverse reactions like fever and liver impairment.
Implementation Method 1
Radioactive microspheres mainly comprise a carrier and a nuclide loaded on the carrier, and the nuclides currently being used in radioactive microspheres include yttrium [90Y], phosphorus [32P], iodine [131I], iodine [125I], technetium [99mTc], rhenium [99mTc], and holmium [166Ho]
Implementation Method 2
the microspheres are injected into the arterial blood supply of the target organ and emit large doses of high-energy rays to kill tumor tissue
Data Source
AI summary
A suspension comprising radioactive microspheres. The radioactive microsphere comprises a resin microsphere and a radionuclide loaded on the resin microsphere, wherein the average particle size of the radioactive microsphere is 25 μm to 40 μm. By means of controlling the proportion of non-spherical microspheres in the radioactive microspheres to be within 5%, the distribution density of the microspheres at a tumor part is increased, the effect of killing tumors is improved, and the treatment safety is improved.