Integrated Radiological Pathological Display Spatial Mapping
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Solution Overview
Problem
Conventional clinical workflows face challenges in effectively integrating radiological and pathological information for accurate diagnosis and therapy selection due to physical separation, geographic constraints, time, and resource limitations, leading to difficulties in establishing spatial correlation between biopsy samples and radiological images, which can result in discordance and unnecessary procedures.
Innovation Solution
A system and method that integrates radiological and pathological information by determining spatial correspondences between biopsy locations and radiological image data, utilizing image analytics and additional information from advanced biomarkers to provide automated reading and evaluation, enabling an integrated display of histological and radiological images for cancer grading, prognosis prediction, and therapy selection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional separate workflows for radiology and pathology are used, then each specialist can independently analyze their own data, but spatial correlation between biopsy samples and radiological images cannot be established
Solution Approach 1:
The patent merges radiological image data and pathological biopsy data into a single integrated digital platform. The system combines PACS (radiology picture archiving) with digital pathology information management, allowing simultaneous display and correlation of radiological images and histological slides with spatial mapping between biopsy locations and anatomical structures.
Solution Approach 2:
The patent introduces a digital coordinate mapping system as an intermediary that bridges radiological and pathological domains. The system uses coordinate transformation algorithms to map biopsy sample locations in pathological space to corresponding anatomical locations in radiological images, enabling precise spatial correlation without direct physical integration of equipment.
2Ease of operation
If digital pathology consultation protocol is implemented, then communication among clinicians is improved, but spatial correlation between biopsy locations and radiological images remains impossible
Solution Approach 1:
The patent adds a spatial coordinate dimension to the digital consultation platform. By implementing 3D coordinate systems and spatial mapping capabilities, the system preserves and visualizes the spatial relationships between biopsy locations and radiological anatomy, transforming 2D image consultation into 3D spatially-aware diagnosis.
Solution Approach 2:
The patent creates digital copies of both radiological images and pathological slides with embedded coordinate metadata. These digital replicas maintain the spatial information of original samples and images, allowing remote consultation while preserving precise location data through coordinated mapping between different imaging modalities.
3Reliability
If multiple separate systems are used for radiology and pathology, then specialized analysis can be performed, but integration and consensus of findings become difficult
Solution Approach 1:
The patent implements a universal digital platform that handles multiple functions: radiological image storage and display, digital pathology slide management, coordinate transformation, spatial mapping, and collaborative consultation. This multi-functional system replaces multiple separate specialized systems while maintaining their individual capabilities and adding integration functionality.
Data Source
AI summary
A method and system for integrating radiological and pathological information for cancer diagnosis, therapy selection, and monitoring is disclosed. A radiological image of a patient, such as a magnetic resonance (MR), computed tomography (CT), positron emission tomography (PET), or ultrasound image, is received. A location corresponding to each of one or more biopsy samples is determined in the at least one radiological image. An integrated display is used to display a histological image corresponding to the each biopsy samples, the radiological image, and the location corresponding to each biopsy samples in the radiological image. Pathological information and radiological information are integrated by combining features extracted from the histological images and the features extracted from the corresponding locations in the radiological image for cancer grading, prognosis prediction, and therapy selection.