Radiopaque Polypeptide Injectable Compositions for Full Absorbability
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Solution Overview
Problem
Current injectable shear-thinning compositions lack full absorbability and sufficient radiopacity for enhanced imaging during and after injection, particularly in applications requiring complete component absorption.
Innovation Solution
Incorporation of iodinated polypeptide-containing molecules, such as iodinated collagen-based proteins, and silicate microparticles into injectable compositions to achieve radiopacity while maintaining absorbability, along with optional additives like therapeutic agents and imaging agents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Illumination intensity
If tantalum particles are used to provide radiopacity in injectable compositions, then radiopacity is improved, but full absorbability is worsened because tantalum is not resorbable
Solution Approach 1:
The patent changes the material parameter from tantalum particles to iodinated polypeptide-containing molecules. This substitution maintains radiopacity through iodine's high atomic number while achieving full absorbability through the polypeptide's biodegradability and resorbability, directly resolving the contradiction between radiopacity and absorbability
Solution Approach 2:
The patent uses composite materials by combining iodinated polypeptide-containing molecules with silicate microparticles. The iodinated polypeptide provides radiopacity and is fully absorbable, while the silicate microparticles provide structural support and are also resorbable, creating a composite that achieves both radiopacity and full absorbability simultaneously
2Illumination intensity
If iodinated polypeptide-containing molecules are used to achieve radiopacity, then radiopacity is improved, but manufacturing complexity is worsened due to multiple coupling processes
Solution Approach 1:
The patent segments the iodination process into distinct coupling steps: first forming activated-ester-substituted intermediates, then coupling with polypeptide amine groups. This segmentation allows each step to be optimized independently and enables modular synthesis, reducing overall manufacturing complexity despite the multi-step process
Solution Approach 2:
The patent uses activated-ester-substituted iodinated molecules as intermediaries in the coupling process. These intermediaries facilitate the attachment of iodine to polypeptide chains through amide coupling, simplifying the overall manufacturing process by providing a reactive intermediate that enables efficient bond formation
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compositions provide enhanced radiopacity for improved imaging and full absorbability, ensuring effective visualization and complete component absorption without the need for non-absorbable radiopaque materials.
Implementation Method 1
radiopaque polypeptides for injectable compositions... iodinated polypeptide-containing molecules... enhanced radiopacity for improved imaging
Implementation Method 2
silicate microparticles... full absorbability... complete component absorption
Implementation Method 3
injectable shear-thinning compositions... material shear-thins and flows readily... ease of delivery
Data Source
AI summary
In some aspects, the present disclosure pertains to injectable compositions that comprise (a) iodinated polypeptide-containing molecules, (b) silicate microparticles, and (c) water. In other aspects, the present disclosure pertains to kits that comprise one or more containers that contain such an injectable composition and a delivery device. In still other aspects, the present disclosure pertains to medical procedures that comprise administering such an injectable composition to a subject.