Radiotherapy Setup Error Quantification Using Encapsulation Metrics

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Solution Overview

Problem

Existing radiotherapy systems lack simple, quantifiable metrics to accurately assess changes in patient anatomy between planning and treatment sessions, leading to potential misalignment of Clinical Volumes (CV) and Planning Envelope Volumes (PEV), which can result in inadequate radiation delivery or exposure to sensitive organs.

Innovation Solution

A method to determine an encapsulation metric by defining Clinical Volumes and Planning Envelope Volumes, calculating the shortest distance of representative points, and using a signed distance transform to quantify the extent of CV encapsulation within PEV, allowing for real-time monitoring and adjustment.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If visual comparison of planning and treatment images is performed manually, then user judgment can be applied, but quantifiable metrics and automation are lacking

Engineering Contradiction:
ImproveCV-PEV alignment assessmentVSAvoidalignment monitoring
Core Design Contradiction:
Measurement precisionVSExtent of automation

Solution Approach 1:

The patent replaces manual visual comparison with an automated computational system that calculates an encapsulation metric. The system uses image processing algorithms to automatically determine the degree of overlap between CV and PEV, substituting human judgment with quantitative computational analysis.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent introduces an encapsulation metric as an intermediary quantitative measure between the planning and treatment images. This metric serves as a mediator that translates complex spatial relationships into a single quantifiable value that can be automatically assessed and tracked.

Inventive Principle:
Principle #24Intermediary (Mediator)

2Reliability

If margins are applied to create PTV and PRV to account for position variation, then robustness to anatomical changes is improved, but the complexity of treatment planning increases

Engineering Contradiction:
Improveradiation delivery accuracyVSAvoidtreatment planning process
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent implements a feedback mechanism that monitors the actual position of CV relative to PEV during treatment and provides quantitative information about alignment. This feedback allows clinicians to adjust patient positioning or treatment parameters based on measured deviations, improving reliability while managing complexity through automated measurement.

Inventive Principle:
Principle #23Feedback

3Productivity

If automated position correction is implemented, then treatment efficiency is improved, but the ability to detect and quantify alignment errors before correction is reduced

Engineering Contradiction:
Improvetreatment session throughputVSAvoidalignment error quantification
Core Design Contradiction:
ProductivityVSLoss of information

Solution Approach 1:

The patent performs preliminary quantification of alignment errors by calculating the encapsulation metric before any position correction is applied. This preliminary assessment preserves information about the original misalignment, allowing clinicians to understand the magnitude and direction of errors before automated correction systems adjust patient positioning.

Inventive Principle:
Principle #10Preliminary action

Data Source

PatentEP4507782B1A method for quantifying patient set up errors in radiotherapy
Publication Date: 2026.03.18 BOSTON SCIENTIFIC SCIMED INC
  • EP4507782B1 patent drawingFigure 1
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  • EP4507782B1 patent drawingFigure 3

AI summary

A method and system for determining changes between a planning image and a treatment image of a subject is described. The method comprising the steps of: defining one of more clinical volumes on the planning image of a subject and defining a planning envelope volume around the clinical volume for the planning image; acquiring a treatment image from the subject for a location corresponding to the location of the planning image; wherein the treatment image will have the same planning envelope volume as the planning image; determining the location of the one or more clinical volumes on the treatment image relative to the planning envelope volume; determining an encapsulation metric for one or more of the clinical volumes defining the extent of encapsulation of the clinical volume on the treatment image within the planning envelope volume on the treatment image.