Three-Dimensional Raman Mapping for Stable Flowable Samples

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Solution Overview

Problem

Existing three-dimensional mapping technologies struggle to accurately measure large, fluid samples due to shaking and instability, limiting their ability to perform confocal image mapping effectively.

Innovation Solution

A three-dimensional Raman image mapping device using a micro Raman spectrometer and a three-axis sample stage with a transparent window and piezo element to stabilize and move flowable samples, enabling confocal image mapping by physically fixing the sample and moving it in the x-, y-, and z-axes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If a flowable sample is measured using conventional three-dimensional mapping technology, then measurement capability is provided, but the sample shakes and becomes unstable, preventing accurate confocal image mapping

Engineering Contradiction:
Improvesample stabilityVSAvoidmeasurement capability
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

The sample stage is divided into multiple independent piezo elements (first, second, third piezo elements) that can be controlled separately. This segmentation allows independent adjustment of each piezo element to compensate for sample shaking, thereby improving sample stability while maintaining measurement capability

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The system uses detection means to detect the position of the objective lens and feedback control mechanisms to adjust the piezo elements accordingly. This feedback loop continuously monitors and corrects sample position, ensuring stability during confocal image mapping measurement

Inventive Principle:
Principle #23Feedback

2Reliability

If a transparent window is added to physically fix the flowable sample, then sample stability is improved, but device complexity increases

Engineering Contradiction:
Improvesample stabilityVSAvoiddevice structure
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The transparent window serves multiple functions: it physically supports the flowable sample to prevent shaking, allows laser light to pass through for Raman measurement, and provides a reference surface for positioning. This multi-functionality improves sample stability without proportionally increasing device complexity

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

The transparent window acts as an intermediary between the sample and the measurement system. It provides mechanical support to stabilize the flowable sample while being transparent to allow optical measurement, thus resolving the contradiction between stability and measurement capability

Inventive Principle:
Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables stable, three-dimensional confocal image mapping of large, fluid samples by preventing shaking and allowing precise movement, facilitating detailed internal component analysis without destruction.

Implementation Method 1

a three-axis sample stage (Piezo stage)

Methodology Applied
Scientific EffectPiezoelectric effect: Piezoelectric Effect

Data Source

PatentEP3951336B1Three-dimensional raman image mapping measurement device for sample with elasticity
Publication Date: 2025.09.10 P&K SKIN RES CENT
  • EP3951336B1 patent drawingFigure 1~2
  • EP3951336B1 patent drawingFigure 3~4
  • EP3951336B1 patent drawingFigure 5~6

AI summary

Disclosed is a three-dimensional Raman image mapping measuring device for a flowable sample, wherein the measuring device is designed to be capable of measuring a flowable sample during mapping measurement of a three-dimensional image that is a region of a confocal Raman by using a micro Raman spectrometer and a three-axis sample stage (Piezo stage). A three-dimensional Raman image mapping measuring device for a flowable sample according to the present invention includes: at least one piezo element; an element holder equipped with the piezo element and having an opening; a sample stage for supporting the element holder equipped with the piezo element; an objective lens mounted in the opening in the element holder; a sample holder for controlling vertical movement of the flowable sample disposed under the lower portion of the sample stage; and a transparent window disposed between the sample stage and the sample holder.