Raman Signal Detection Using Orthogonal Modulation
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Solution Overview
Problem
Conventional Raman signal detection systems for physiological analysis are expensive and have limited throughput due to the use of grating-based spectrometers, making them unsuitable for low-cost, high-throughput monitoring of physiological parameters.
Innovation Solution
A low-cost, high-throughput Raman signal detection system is achieved by modulating the Raman signal using a plurality of optical filters and modulators to generate orthogonal components, which are then demodulated to determine the analyte content based on the intensities of these components, utilizing a single detector and eliminating the need for dispersive components like gratings.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a Grating-CCD or Grating-photodiode-array spectrometer is used for Raman signal detection, then measurement precision is improved, but device complexity and cost increase significantly
Solution Approach 1:
The patent extracts the dispersive function (grating) from the detection system and replaces it with a simpler single-detector configuration combined with wavelength scanning, eliminating complex optical components while maintaining detection capability
Solution Approach 2:
The patent uses a single detector to sequentially detect different wavelength components of the Raman signal by scanning, effectively copying the spectral information detection capability of multi-detector systems through time-multiplexed measurement
2Measurement precision
If a Grating-CCD or Grating-photodiode-array spectrometer is used for Raman signal detection, then measurement precision is improved, but productivity decreases due to limited throughput
Solution Approach 1:
The patent employs periodic wavelength scanning to sequentially detect different spectral components, enabling continuous data acquisition that improves throughput compared to static grating-based systems while maintaining spectral resolution through systematic scanning
3Productivity
If a single-detector system with sweeping light source or tunable filter is used to achieve high throughput, then productivity is improved, but device complexity and cost increase
Solution Approach 1:
The patent makes a single detector perform multiple functions by sequentially detecting different wavelength components through scanning, eliminating the need for separate detectors for each wavelength band and simplifying the overall system architecture
Solution Approach 2:
The patent replaces complex mechanical dispersive systems (gratings) with a simpler scanning mechanism that directs different wavelengths to a single detector, reducing mechanical complexity while achieving similar spectral analysis capability
Data Source
AI summary
A Raman signal detection and analyzing system and a method thereof are disclosed. The Raman signal is generated by emitting an excitation light to a sample. The Raman signal is then modulated by passing through a plurality of optical filter and modulator. The resulting modulated Raman signal comprises two orthogonal components, which intensities are to be computed based on the first harmonic of said modulated Raman signal. The content of a specific analyte within the sample can then be determined based on the ratio of the intensities of the two components.