Raman Probe Lens Group Stabilizes Focusing
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Solution Overview
Problem
Hand-held Raman spectroscopy probes face challenges in achieving accurate focusing due to operator hand shaking, leading to reduced Raman signal reliability and stability, especially in clinical environments with variable depths and angles, affecting the sensitivity and repeatability of tumor detection.
Innovation Solution
A Raman spectroscopy probe with an optical fiber module and a magnifying lens group, where the detection window is positioned near the object distance of the lens, allowing precise focusing and increasing the power density of the excitation light, similar to confocal scanning Raman microscopes, while maintaining portability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If the focusing position is non-contact with a certain distance, then the probe structure is simple and portable, but the Raman signal intensity and measurement reliability are significantly reduced due to energy dispersion
Solution Approach 1:
The probe is divided into functional modules: excitation light source module, magnifying lens group, detection window, and collection module. This segmentation allows each component to be optimized independently, achieving high signal intensity through precise optical design while maintaining overall portability.
Solution Approach 2:
A detection window is introduced as an intermediary component between the magnifying lens group and the target object. This window serves as a reference plane that enables accurate focusing and contact measurement, bridging the gap between the optical system and the tissue being examined.
2Adaptability or versatility
If the probe is held by hand for flexible measurement, then the portability and adaptability are improved, but the focusing stability and repeatability deteriorate due to operator hand shaking
Solution Approach 1:
The magnifying lens group provides excessive magnification beyond what is strictly necessary, creating a larger depth of field and more tolerant focusing range. This partial over-engineering of the optical system compensates for hand shaking effects while maintaining hand-held flexibility.
Solution Approach 2:
The detection window serves as a self-reference standard that automatically indicates when proper contact and focusing are achieved. The operator simply needs to make contact with the tissue, and the system self-regulates to provide stable measurements without requiring precise manual positioning.
3Measurement precision
If a magnifying lens group is added to achieve precise focusing, then the spatial resolution and power density are improved, but the device complexity and length increase
Solution Approach 1:
The magnifying lens group consists of multiple convex lenses nested in sequence, where each lens contributes to the overall magnification while sharing common optical paths. This nested arrangement achieves high spatial resolution without requiring excessive probe length, as the lenses work cooperatively rather than requiring separate optical trains.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution enhances the sensitivity and spatial resolution of Raman detection, stabilizes the focusing position, and improves measurement reliability, enabling high-precision tumor detection comparable to confocal scanning Raman microscopes, while maintaining the portability and flexibility of hand-held probes.
Implementation Method 1
a magnifying lens group and a detection window that are arranged on an optical path of the optical fiber module in sequence... the magnifying lens group includes a plurality of convex lenses that are arranged in sequence... focal lengths of the plurality of convex lenses in the magnifying lens group are each f
Implementation Method 2
increasing the power density of the excitation light, similar to confocal scanning Raman microscopes
Implementation Method 3
the detection window is located near a position of an object distance of a lens, close to a detection end... enabling a target object to be located just at the best focusing position
Implementation Method 4
the optical fiber module includes an excitation fiber (excitation optical fiber)... transmitting the returned detection signals of the detection end
Implementation Method 5
Raman spectroscopy is a new type of optical diagnostic technology... analyze the molecular composition and content in tumor tissues, and realize high-precision diagnosis by collecting the 'Raman fingerprint' of tumors
Data Source
AI summary
A Raman spectroscopy probe and a Raman spectroscopy detection device are provided including an optical fiber module, and a magnifying lens group and a detection window sequentially arranged on an optical path thereof, wherein the optical fiber module includes an excitation fiber and parallel collection fibers surrounding a periphery thereof; the magnifying lens group includes sequentially-arranged convex lenses, the detection window is located near an object-distance position of a lens close to a detection end. A distance between two adjacent convex lenses is equal to a sum of former's image and latter's object distance. Focal lengths of the convex lenses in the magnifying lens group are f, and satisfy a ratio of the object distance to the image distance of n:1, and a length L of the magnifying lens group satisfies:L=n+2+1nlog10n·f·log10N,whereinn=Nm,N is a magnification, and m is a number of the convex lenses.