Ramulus Mori Extract Inhibits Adipocyte Differentiation

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Solution Overview

Problem

Current anti-obesity medications often come with side effects such as mental illness, myocardial infarction, and gastrointestinal issues, prompting the need for safer alternatives that can inhibit adipocyte differentiation and lipid accumulation.

Innovation Solution

A composition containing an ethanolic extract of Ramulus mori, which suppresses lipid accumulation and inhibits adipocyte differentiation by reducing the expression of transcription factors like PPAR-γ, C/EBP-α, and SREBP-1, potentially used as a pharmaceutical or food composition.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If commercial anti-obesity medicines are used to suppress obesity, then obesity suppression effect is improved, but side effects such as mental illness, myocardial infarction, and gastrointestinal issues occur

Engineering Contradiction:

Improveobesity suppression effectVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent changes the chemical composition parameters by using natural product extracts (polyphenols, flavonoids, terpenes) instead of synthetic pharmaceutical compounds. This parameter change maintains obesity suppression efficacy while eliminating the harmful side effects associated with conventional anti-obesity medications.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent employs natural product extracts that can be safely consumed and metabolized by the body, replacing long-term synthetic medications with naturally derived compounds that are biodegradable and excreted without accumulation, thus avoiding chronic side effects.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

2Loss of information

If adipocyte differentiation is promoted to understand obesity mechanism, then research insight is improved, but lipid accumulation increases leading to obesity

Engineering Contradiction:

Improveobesity mechanism understandingVSAvoidlipid accumulation

Core Design Contradiction:

Loss of informationVSQuantity of substance

Solution Approach 1:

The patent extracts and isolates the differentiating factor (adipocyte differentiation) from the complex obesity phenomenon, allowing researchers to study the mechanism in controlled conditions while using natural extracts to prevent the harmful lipid accumulation that would otherwise result from such differentiation studies.

Inventive Principle:

Principle #2Taking out (Extraction)

Solution Approach 2:

The patent introduces natural product extracts as intermediary substances that modulate adipocyte differentiation processes, enabling researchers to observe and study the differentiation mechanism without allowing uncontrolled lipid accumulation to occur.

Inventive Principle:

Principle #24Intermediary (Mediator)

Data Source

PatentUS11291704B2Composition for preventing or treating obesity containing ethanolic extract of <i>Ramulus mori</i>

Publication Date: 2022.04.05 KOREA UNIV RES & BUSINESS FOUND

AI summary

The present invention relates to a composition for preventing or treating obesity containing an ethanolic extract of Ramulus mori as an active ingredient. As the present invention contains an ethanolic extract of Ramulus mori, extracted from natural substance Ramulus mori, as an active ingredient, the present invention may prevent or treat obesity by inhibiting lipid accumulation in adipocytes without any side effects to a human body and inhibiting preadipocytes from being differentiated into adipocytes.