Rapid Test Strip Label Layout for Longer Analyte Reaction
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Solution Overview
Problem
Conventional rapid test strips have insufficient reaction time between the test subject and biomolecules, leading to poor color development and inaccurate detection for samples requiring longer reaction times.
Innovation Solution
A rapid test strip design with a sample pad having an upstream end portion farther from the reaction pad, where biomolecule labels are applied to increase the reaction time with target biomolecules, and a bioreaction layer covering the boundary line between the end portions, ensuring sufficient contact and reaction time.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If the conjugate pad is made short to reduce device length, then the device complexity is reduced, but the reaction time between test subject and biomolecules becomes insufficient
Solution Approach 1:
The sample pad is segmented into distinct functional zones: an upstream end portion for initial sample absorption and a downstream end portion for continued reaction. This segmentation allows the reaction process to occur in stages, extending the effective reaction time without requiring a longer overall device length. The biomolecule labels are specifically disposed on the upstream end portion to maximize interaction time with the test subject.
Solution Approach 2:
The invention extends the reaction path by utilizing the width dimension of the sample pad. Instead of relying solely on the length of the conjugate pad, the biomolecule labels are distributed across the upstream end portion in a manner that allows test subject to interact with multiple labels simultaneously or sequentially as it moves through the pad, effectively increasing reaction time without increasing device length in the primary flow direction.
2Ease of manufacture
If the conjugate pad is made short to simplify manufacturing, then the ease of manufacture is improved, but the color development quality deteriorates
Solution Approach 1:
The sample pad is designed with non-uniform biomolecule label distribution, concentrating the labels on the upstream end portion where the test subject first contacts the pad. This local concentration ensures that the most critical reaction occurs in the zone with maximum interaction time, while the downstream end portion provides continued reaction support. This local quality approach maintains manufacturing simplicity while ensuring high color development quality through optimized label placement.
3Device complexity
If the biomolecule labels are disposed only on the conjugate pad, then the device structure is simplified, but the reaction time is insufficient for slow-reacting substances
Solution Approach 1:
The biomolecule labels are pre-disposed on the upstream end portion of the sample pad, positioned to contact the test subject immediately upon application. This preliminary positioning ensures that the reaction process begins at the optimal location with maximum interaction time available. The upstream end portion acts as a pre-reaction zone where slow-reacting substances can begin their reaction process before continuing to the downstream end portion, effectively extending the total reaction time without complicating the overall device structure.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enhances reaction time and accuracy of color development for samples like lipophilic hydrophobic molecules, such as THC, by allowing sufficient interaction with biomolecule labels, improving detection precision.
Implementation Method 1
After being absorbed by the sample pad, the test subject flows to the conjugate pad via capillary action
Implementation Method 2
the plurality of biomolecule labels are configured to bond to a plurality of target biomolecules of the sample
Data Source
AI summary
A rapid test strip is provided, wherein the rapid test strip includes a base layer, a sample pad, a reaction pad and an absorption pad, the sample pad, the reaction pad and the absorption pad are sequentially disposed on the base layer, the sample pad is configured to absorb a sample, the sample pad includes an upstream end portion, a downstream end portion and a plurality of biomolecule labels, the upstream end portion is farther from the reaction pad than the downstream end portion, the plurality of biomolecule labels are at least disposed on the upstream end portion, and the plurality of biomolecule labels are configured to bond to a plurality of target biomolecules of the sample.