Raspberry Extract and Hydroxyproline Synergy for Elastase Inhibition
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Solution Overview
Problem
Current cosmetic external skin preparations lack effective inhibitors to prevent elastase-induced skin aging, which leads to reduced skin resiliency and tightness, and existing elastase inhibitors often rely on synthetic chemicals rather than natural ingredients.
Innovation Solution
A cosmetic external skin preparation containing raspberry extract and hydroxyproline, where the raspberry extract demonstrates elastase inhibitory activity, and the addition of hydroxyproline synergistically enhances this activity, potentially preventing elastase-induced skin aging by maintaining skin resiliency and tightness.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If natural ingredients are used as elastase inhibitors in cosmetic preparations, then safety and skin compatibility are improved, but elastase inhibitory activity and effectiveness are insufficient compared to synthetic inhibitors
Solution Approach 1:
The patent combines raspberry extract (containing ellagic acid and other polyphenols) with hydroxyproline to create a synergistic formulation. The raspberry extract provides natural elastase inhibitory activity while hydroxyproline enhances this effect, achieving both natural ingredient safety and sufficient inhibitory activity against elastase-induced skin aging
Solution Approach 2:
The invention creates a composite cosmetic preparation containing multiple natural and semi-natural components: raspberry extract (natural plant extract), hydroxyproline (amino acid derivative), and other auxiliary ingredients. This composite formulation achieves enhanced elastase inhibition through the synergistic interaction of its components while maintaining safety for skin application
2Reliability
If existing natural elastase inhibitors are used individually, then skin safety is maintained, but the elastase inhibition effect is insufficient to prevent skin aging
Solution Approach 1:
The patent merges raspberry extract with hydroxyproline in a specific formulation to achieve synergistic elastase inhibition. The combination produces a stronger anti-aging effect than either ingredient alone, effectively preventing elastin degradation while maintaining skin safety
Solution Approach 2:
The invention optimizes the concentration parameters of raspberry extract (0.01-10% by weight) and hydroxyproline (0.1-5% by weight) to achieve maximum synergistic effect. By carefully controlling these parameter ranges, the formulation achieves potent elastase inhibition while maintaining safety for cosmetic application
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination of raspberry extract and hydroxyproline in a cosmetic preparation effectively inhibits elastase, enhancing skin resiliency and preventing the denaturation of elastin, thereby addressing skin aging issues while using natural ingredients.
Implementation Method 1
elastase inhibitors are also known to be useful in the treatment of disease... the selective neutrophil elastase inhibitor, sivelestat sodium, which is effective for improving acute lung disorders... the incorporated amount of raspberry fruit extract... and the incorporated amount of hydroxyproline... for inhibiting elastase
Data Source
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AI summary
An elastase inhibitor that contains as active ingredients thereof raspberry extract and hydroxyproline, and optionally further contains yeast extract.