Raspberry-Shaped Biodegradable Microparticles for Dermal Fillers
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Solution Overview
Problem
Biodegradable polymer microparticles used as dermal fillers face challenges in cell adsorption due to their smooth surface, which slows down the self-collagen generation process, and widening the surface area with acute angles can cause tissue piercing side effects.
Innovation Solution
The development of biodegradable polymer microparticles with a raspberry-shaped structure and a core-shell configuration, where the shell has a raspberry-shaped structure and an average particle diameter of 20 to 200 µm, enhancing cell adsorption by increasing the surface area while maintaining a curved surface to prevent tissue piercing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Area of moving object
If the surface area of biodegradable polymer microparticles is widened to improve cell adsorption, then the efficiency of self-collagen generation stimulation is improved, but the microparticles may cause side effects by piercing tissues if the surface has acute angles
Solution Approach 1:
The patent applies spheroidality by designing microparticles with a raspberry-shaped surface that features curved protuberances instead of sharp edges. The surface is characterized by multiple rounded bumps with a diameter of 1-10 µm, creating a curvature radius of 0.5-5 µm. This curved geometry increases the surface area for cell adsorption while eliminating acute angles that would cause tissue piercing, thus resolving the technical contradiction between surface area expansion and tissue safety.
2Ease of manufacture
If the surface of biodegradable polymer microparticles is smooth, then the manufacturing process is simple, but cell adsorption is hindered and the self-collagen generation process slows down
Solution Approach 1:
The patent applies the porous materials principle by creating a raspberry-shaped surface structure with multiple protuberances on the microparticle surface. This structure increases the effective surface area by approximately 2-3 times compared to smooth spherical particles, providing more adsorption sites for cells and macrophages. The porous-like textured surface enhances cell interaction and accelerates self-collagen generation while maintaining a manufacturing process that uses standard emulsion polymerization techniques.
3Duration of action of stationary object
If biodegradable polymer microparticles are used as dermal fillers, then they can be decomposed over a long time providing wrinkle improvement effect, but they cause Foreign body reaction due to not existing in the human body
Solution Approach 1:
The patent applies parameter changes by modifying the surface characteristics of the biodegradable polymer microparticles through raspberry-shaped structuring. This surface modification changes the physical parameters (surface area, surface roughness) to enhance biocompatibility and cell interaction. The increased surface area and curved geometry promote beneficial foreign body reactions that stimulate collagen production rather than harmful inflammatory responses, while maintaining the long-term degradation profile of 6 months to 4 years for sustained wrinkle improvement.
Data Source
Figure 1a
Figure 1b
Figure 2a~2b
AI summary
Disclosed herein are a biodegradable polydioxanone microparticle for a filler comprising a core and a shell, wherein the core contains secondary particles including aggregates of a plurality of primary particles, the shell has a raspberry shaped structure, an average particle diameter (D50) of the biodegradable polymer microparticle ranges from 20 to 200 µm, a manufacturing method thereof, a freeze-dried body including the same, and filler injection including the same.