RBD Nanoparticle Booster Composition for Durable Variant Immunity

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Solution Overview

Problem

The global pandemic of SARS-COV-2 virus has resulted in increased deaths and socioeconomic damage, necessitating rapid vaccine development to prevent and alleviate SARS-COV-2 infections, including variants, and existing vaccines may not maintain high levels of IgG and neutralizing antibodies without side effects.

Innovation Solution

A booster vaccine composition comprising receptor binding domain (RBD) nanoparticles, including trimers and pentamers of specific polypeptide monomers, and AS03 adjuvant, administered at least 14 days after a primary vaccine, to induce or maintain an immune response against wild-type and variant SARS-COV-2 viruses.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing vaccine compositions are administered to prevent SARS-COV-2 infection, then immune response is induced, but IgG and neutralizing antibody levels are not maintained at high levels without side effects

Engineering Contradiction:

Improveimmune response maintenanceVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-generated harmful factors

Solution Approach 1:

The vaccine composition uses a composite nanoparticle structure combining RBD trimers and pentamers with specific lipid components (cholesterol, DSPG, and ionizable lipid) to create a stable immunogenic complex that maintains high antibody levels while reducing side effects through optimized material composition

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The invention optimizes the ratio of lipid components (cholesterol:DSPG:ionizable lipid at 45:45:10 mol%) and nanoparticle characteristics to enhance immune response durability while controlling adverse reactions through precise parameter control of the vaccine formulation

Inventive Principle:

Principle #35Parameter changes

2Adaptability or versatility

If vaccine composition is administered to induce immune response against SARS-COV-2, then protection against wild-type virus is achieved, but immunity against variant viruses is insufficient

Engineering Contradiction:

Improvevariant virus coverageVSAvoidprotection level

Core Design Contradiction:

Adaptability or versatilityVSReliability

Solution Approach 1:

The RBD nanoparticle composition is designed to provide universal protection against multiple SARS-CoV-2 variants (including Alpha, Beta, Delta, and Omicron) while maintaining high immunogenicity, achieving both broad adaptability and reliable protection through a single vaccine formulation

Inventive Principle:

Principle #6Universality (Multi-functionality)

Data Source

PatentUS20260014247A1SARS-COV-2 vaccine booster composition

Publication Date: 2026.01.15 SK BIOSCI CO LTD

AI summary

The present disclosure provides a composition for inducing or maintaining an immune response against SARS-COV-2 virus.