Reactive Polysaccharide Hemostatic Powder Crosslinking
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Solution Overview
Problem
Existing powdered and flowable hemostatic agents face challenges such as poor tissue adherence, difficulty in application to hard-to-reach bleeding sites, and insufficient effectiveness due to lack of absorbency and cohesivity, requiring manual compression to maintain their position at the bleeding site.
Innovation Solution
A dry, powdered hemostatic composition comprising modified polysaccharides with electrophilic groups and proteins that crosslink upon exposure to water, forming a hemostatic hydrogel to enhance tissue adherence and control bleeding.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If powdered hemostatic agents are used, then they are easy to store and handle, but they have poor tissue adherence and are washed away easily
Solution Approach 1:
The patent changes the physical and chemical parameters of the hemostatic agent by transforming it from a simple powder to a reactive two-component system that crosslinks in situ. The components are kept separate during storage (maintaining ease of handling) but react together upon contact with blood to form a crosslinked hydrogel network (improving tissue adherence).
Solution Approach 2:
The invention creates a composite hemostatic system combining two distinct components (first component with electrophilic groups and second component with amine groups) that work together synergistically. The composite structure allows each component to maintain its individual advantages while the combination provides enhanced tissue adherence through crosslinking.
2Ease of operation
If flowable hemostatic agents are used, then they can be applied to difficult-to-reach sites, but they lack sufficient cohesivity and require manual compression
Solution Approach 1:
The hemostatic composition transitions from a dynamic liquid state during application (allowing flow into difficult-to-reach sites) to a static crosslinked hydrogel state after application ( providing cohesivity and eliminating need for manual compression). This dynamic state change is triggered by contact with blood.
Solution Approach 2:
The two components are prepared in advance and applied separately to the bleeding site, allowing them to flow into difficult-to-reach areas before crosslinking occurs. This preliminary separation enables better distribution followed by in situ bonding.
3Reliability
If conventional hemostats are used, then they provide immediate hemostasis, but they require manual compression to remain in place
Solution Approach 1:
The hemostatic composition is self-retaining through autonomous crosslinking upon contact with blood. The electrophilic groups on the first component react with amine groups on the second component to form a crosslinked hydrogel that adheres to tissue independently, eliminating the need for manual compression to maintain position.
4Quantity of substance
If powdered hemostats are used, then they have good absorbency, but they lack cohesivity to resist being washed away
Solution Approach 1:
The invention merges the absorbent properties of powdered hemostats with the cohesivity of crosslinked gels. The two-component system combines the high surface area and absorbency of particles with the structural integrity of a crosslinked network, achieving both high absorbency and resistance to being washed away.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The crosslinked hydrogel provides effective hemostasis by improving tissue adherence and reducing the need for manual compression, allowing for better control of bleeding and easier application to difficult sites.
Implementation Method 1
the plurality of polysaccharide chains are functionalized with electrophilic groups capable of reacting with amine groups
Implementation Method 2
The subject matter of the present invention involves, in some cases, interrelated products, alternative solutions to a particular problem, and/or a plurality of different uses of one or more systems and/or articles
Data Source
AI summary
Compositions and methods related to powdered hemostats that crosslink during and/or after application to a bleeding site are generally described.