Reactor Module With Fluid-Driven Film Motion for Cell Culture Testing
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Solution Overview
Problem
Conventional cell reaction simulations in physiological environments require sacrificing large numbers of experimental animals for accuracy, leading to ethical concerns.
Innovation Solution
A reactor module with a culture vessel and supply unit that simulates tissue movements by vertically moving a film member using fluid pressure to mimic living tissue conditions, allowing cell culture observations under controlled conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional simulations using experimental animals are performed to achieve accurate cell reaction analysis, then measurement precision is improved, but loss of life increases
Solution Approach 1:
The patent creates a reactor module that copies the physiological environment of living organisms. It uses a film member that can be stretched and deformed to simulate tissue mechanics, and a culture vessel that replicates biological conditions, allowing cell reactions to be studied without using actual animals while maintaining measurement accuracy.
Solution Approach 2:
The patent introduces an intermediary system - the reactor module with film member and culture vessel - that mediates between the need for accurate biological measurement and the ethical concern of animal sacrifice. This intermediary allows indirect observation of cell reactions under controlled conditions that mimic living tissue without requiring actual animal subjects.
2Adaptability or versatility
If a reactor module with film member is used to simulate tissue movements, then adaptability is improved, but device complexity increases
Solution Approach 1:
The reactor module is segmented into distinct functional components: a lower body for support, an upper body for operation, a film member for tissue simulation, and a culture vessel for cell culture. This segmentation allows each component to be optimized independently while maintaining overall adaptability for simulating various tissue movements.
Solution Approach 2:
The film member is designed to be dynamically deformable, allowing it to stretch and change shape in response to applied forces. This dynamic property enables the system to simulate various tissue movements and mechanical stresses, enhancing adaptability while using a relatively simple flexible membrane rather than complex mechanical actuators.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate and ethical cell reaction simulations without animal sacrifice, providing high applicability and precision in observing cell changes.
Implementation Method 1
The supply unit is adapted to supply a fluid into one of the bottom space of the reactor module and the culture reservoir of the reactor module so as to push and move the central portion of the film member vertically relative to the upper and lower bodies
Data Source
AI summary
A reactor module includes a lower body, an upper body, a top cover and a culture vessel. The lower body defines and surrounds a bottom space that has an upper opening. The upper body is detachably connected atop the lower body. The top cover is disposed atop the upper body, and cooperatives with the upper body to define a receiving space that is disposed above the bottom space. The culture vessel is removably received in the receiving space, defines a culture reservoir, and includes a film member that is disposed under the culture reservoir, and that blocks the upper opening of the bottom space.