Reactor Module for Vascular Flow and Shear Stress Simulation
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Solution Overview
Problem
Conventional methods for simulating vascular bifurcations using computational fluid dynamics are insufficient in accuracy and inefficient in simulating different biological environments due to the inherent intricacy of vascular systems.
Innovation Solution
A biomechanical testing system with a reactor module that includes an upper board, lower board, positioning board, position-limiting member, and biological culture material, which simulates fluidic physiological environments by controlling liquid flow and electrical stimulation through airtight spaces and customizable channels to mimic vascular bifurcations and blockages.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If computational fluid dynamics (CFD) is used to simulate vascular bifurcation models, then the simulation can be performed theoretically, but the accuracy is insufficient and efficiency is low due to the inherent intricacy of vascular systems
Solution Approach 1:
The patent creates physical copies of vascular bifurcation models using 3D printing technology. Instead of relying solely on theoretical CFD simulations, the invention fabricates accurate physical replicas of blood vessels with varying diameters, bifurcation angles, and branch patterns. These physical models are then placed in a controlled flow chamber where fluid dynamics can be directly observed and measured, significantly improving simulation accuracy while maintaining manageable system complexity through standardized modular components.
Solution Approach 2:
The patent replaces the purely computational CFD mechanical system with a hybrid experimental setup. Physical vascular models are subjected to controlled fluid flow in a laboratory setting, allowing direct measurement of hemodynamic parameters. This substitution enables researchers to validate and refine CFD models with empirical data, thereby improving reliability while using the physical models to simplify complex computational requirements.
2Productivity
If conventional CFD methods are used to simulate different biological environments, then the theoretical framework is established, but the simulation efficiency is inefficient due to the varying diameters, bifurcation angles and branch patterns of vascular systems
Solution Approach 1:
The patent designs a universal flow chamber system with standardized interfaces and modular components that can accommodate various vascular models with different diameters, bifurcation angles, and branch patterns. The adjustable flow rate mechanism and interchangeable vascular models allow the same experimental apparatus to simulate multiple biological environments efficiently, eliminating the need for separate computational setups for each scenario and significantly improving productivity.
Solution Approach 2:
The patent implements a dynamic flow control system that can adjust flow rates, pulse frequencies, and pressure gradients in real-time to mimic different physiological conditions. This dynamic capability allows researchers to efficiently simulate various biological environments by simply changing operational parameters rather than redesigning the entire experimental setup, thereby enhancing both efficiency and adaptability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system provides accurate simulations of cyclic fluid shear stress, stable fluid pressure, fluid pulse stimulation, and electrical stimulation, offering high versatility and flexibility in simulating various physiological environments.
Implementation Method 1
The pneumatic pressure source is connected to the storage unit, and is controllable to supply gas into the storage unit so as to drive the liquid to flow from the storage unit into the airtight space and through the at least one biological culture material
Data Source
AI summary
A biomechanical testing system includes a reactor module, a storage unit and a pneumatic pressure source. The reactor module includes an upper board, a lower board, a positioning board disposed between and cooperating with the upper and lower boards to define an airtight space, a position-limiting member received in the airtight space, and at least one biological culture material positioned in the airtight space by the position-limiting member. The storage unit is adapted to supply a liquid to the airtight space. The pneumatic pressure source is controllable to supply gas to the storage unit so as to drive the liquid to flow from the storage unit into the airtight space and through the at least one biological culture material.


