Reagent Container Inversion Mixing for Dissolution Accuracy

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Solution Overview

Problem

Existing automatic analysis devices face challenges in accurately dissolving freeze-dried reagents without manual intervention, leading to potential liquid leaks and inefficiencies, as current automation solutions either fail to maintain a sealed state during solvent dispensing or require complex film management.

Innovation Solution

An automated device with a reagent container, dispensing mechanism, inversion mixing mechanism, and control unit that rotates and tilts the reagent container to maintain the solvent opening above the liquid surface, ensuring accurate solvent dispensing and mixing without leaks, using a tubular lid mechanism and controlled dispensing conditions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Manufacturing precision

If manual inversion mixing is performed after dispensing solvent into freeze-dried reagent, then dissolution accuracy is improved, but labor effort and time consumption increase

Engineering Contradiction:
Improvedissolution accuracyVSAvoidtime consumption
Core Design Contradiction:
Manufacturing precisionVSLoss of time

Solution Approach 1:

The reagent container is designed to perform self-mixing through its own rotation and tilting movements. The container rotates around its central axis and simultaneously tilts at a predetermined angle, creating automatic inversion mixing without requiring external manual intervention. This self-service mechanism eliminates the need for users to manually invert and mix the reagent, thereby reducing labor effort and time consumption while maintaining dissolution accuracy.

Inventive Principle:
Principle #25Self-service

2Manufacturing precision

If manual inversion mixing is performed, then dissolution accuracy is improved, but liquid leakage risk increases

Engineering Contradiction:
Improvedissolution accuracyVSAvoidliquid leakage prevention
Core Design Contradiction:
Manufacturing precisionVSReliability

Solution Approach 1:

The opening of the reagent container is preliminarily sealed with a seal member before the solvent dispensing and mixing process begins. This preliminary sealing action ensures that the container remains sealed during the automatic rotation and tilting movements, preventing liquid leakage while allowing the inversion mixing to proceed effectively for accurate dissolution.

Inventive Principle:
Principle #10Preliminary action

3Extent of automation

If automation of inversion mixing is implemented, then labor saving is achieved, but device complexity increases

Engineering Contradiction:
Improveautomation levelVSAvoidmechanism complexity
Core Design Contradiction:
Extent of automationVSDevice complexity

Solution Approach 1:

The reagent container is designed with multi-functionality, serving both as the storage vessel for the freeze-dried reagent and as the mixing mechanism itself. The container incorporates rotation and tilting capabilities, allowing it to perform both storage and automatic inversion mixing functions. This universal design achieves automation without requiring separate complex mixing devices, thereby limiting the increase in overall device complexity.

Inventive Principle:
Principle #6Universality (Multi-functionality)

4Ease of operation

If the reagent container is opened for solvent dispensing, then solvent access is improved, but liquid spill-out risk increases during mixing

Engineering Contradiction:
Improvesolvent dispensing easeVSAvoidliquid spill-out prevention
Core Design Contradiction:
Ease of operationVSReliability

Solution Approach 1:

The opening of the reagent container is preliminarily sealed with a seal member before the solvent dispensing and mixing process begins. This preliminary sealing action ensures that the container remains sealed during the automatic rotation and tilting movements, preventing liquid spill-out while allowing effective inversion mixing to occur.

Inventive Principle:
Principle #10Preliminary action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enables automated, efficient, and accurate dissolution of freeze-dried reagents, reducing user labor and preventing reagent spills, thereby enhancing analysis precision and efficiency.

Implementation Method 1

an inversion mixing mechanism for subjecting the reagent container to inversion mixing

Methodology Applied
Scientific EffectGravitation: Gravitation

Implementation Method 2

a rotating mechanism for rotating the reagent container and a tilting mechanism for tilting a rotating shaft of the reagent container

Methodology Applied
Scientific EffectMechanical mixing: Stirring

Data Source

PatentUS11293935B2Automatic analysis device
Publication Date: 2022.04.05 HITACHI HIGH TECH CORP
  • US11293935B2 patent drawing
  • US11293935B2 patent drawing
  • US11293935B2 patent drawing

AI summary

An automatic analysis device includes a reagent container, a reagent disk for holding the reagent container, a dispensing mechanism for dispensing a solution into the reagent container, an inversion mixing mechanism for subjecting the reagent container to inversion mixing, and a control unit for controlling the dispensing mechanism and the inversion mixing mechanism. The inversion mixing mechanism has a rotating mechanism for rotating the reagent container and a tilting mechanism for tilting a rotating shaft of the reagent container. The reagent container has a lid which can be pierced. The lid has a tubular mechanism having an opening part formed at the tip end and extending inside the reagent container. The control unit controls the dispensing conditions of the dispensing mechanism.