Reagent Determination Means for Sample Analyzer Standard Curve Management

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Solution Overview

Problem

In sample analyzers, the lack of a standard curve for reagents leads to measurement errors and waste, as the usage order of reagents is not determined when multiple reagents of the same type are present, causing incorrect analysis results and inefficient reagent management.

Innovation Solution

A sample analyzer with a reagent container holder, measurement specimen preparer, memory for storing standard curve data, and reagent determination means to determine the appropriate reagent for analysis based on stored standard curve information, ensuring accurate and efficient use of reagents.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If multiple reagents of the same type are held in the reagent container holder, then the reagent running out during analyzing process is prevented, but the usage order of reagents cannot be determined leading to incorrect analysis results

Engineering Contradiction:
Improveanalysis result accuracyVSAvoidreagent management complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The system performs preliminary determination of the usage order of reagents by checking standard curve data availability before actual measurement. The reagent determination means identifies which reagent should be used first based on pre-stored standard curve information, establishing the correct usage sequence in advance to prevent incorrect analysis results.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The system uses feedback from standard curve data storage to guide reagent selection. The memory stores standard curve data corresponding to reagents, and the reagent determination means uses this feedback information to automatically determine the correct reagent usage order, ensuring accurate analysis results while managing multiple reagents.

Inventive Principle:
Principle #23Feedback

2Productivity

If measurement is performed using reagents without created standard curves to complete sample measurement early, then the sample can be sent to next examination sooner, but the analysis result cannot be obtained and reagent waste occurs when standard curve errors are discovered

Engineering Contradiction:
Improvesample measurement throughputVSAvoidreagent waste
Core Design Contradiction:
ProductivityVSLoss of substance

Solution Approach 1:

The system performs preliminary verification of standard curve data availability before initiating measurement with a specific reagent. The reagent determination means checks whether standard curve data exists for each reagent in advance, and only selects reagents with available standard curves, preventing subsequent measurement errors and reagent waste.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The system automatically determines the correct reagent usage order by referencing stored standard curve data without requiring manual intervention. The reagent determination means autonomously identifies which reagent to use first based on the standard curve information, ensuring both accurate results and efficient reagent utilization.

Inventive Principle:
Principle #25Self-service

3Measurement precision

If the standard curve is created by measuring calibrator, then accurate analysis results can be obtained, but the sample cannot be measured in the meantime causing time loss

Engineering Contradiction:
Improveanalysis result accuracyVSAvoidsample measurement delay
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The system stores standard curve data in advance in the memory corresponding to reagents before actual sample measurement occurs. This preliminary preparation allows the reagent determination means to immediately identify the correct reagent with available standard curve data when sample measurement is needed, eliminating time delays.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The system uses stored standard curve data (a copy of the calibration information) to determine reagent usage order without requiring real-time creation of standard curves. The pre-stored standard curve data serves as a reference copy that enables immediate and accurate reagent selection for sample measurement.

Inventive Principle:
Principle #26Copying

Data Source

PatentUS8071029B2Sample analyzer and sample analyzing method
Publication Date: 2011.12.06 SYSMEX CORP
  • US8071029B2 patent drawing
  • US8071029B2 patent drawing
  • US8071029B2 patent drawing

AI summary

A sample analyzer and sample analyzing method perform following: a) mixing a sample with at least one of a first reagent and a second reagent, thereby preparing a measurement specimen; b) storing, in a memory, standard curve data corresponding to a reagent to be used in the step a) for preparing a measurement specimen; c) measuring the measurement specimen thereby obtaining measurement data; d) processing the measurement data based on the standard curve data, thereby obtaining an analysis result; and e) when the first, reagent and the second reagent are of the same type, determining a reagent to be used for the measuring between the first reagent and the second reagent, based on information regarding standard curve data stored in the memory.