Reagent Storage Partition Seal for Stability
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Solution Overview
Problem
Storing multiple reagents together can lead to instability, increasing manufacturing complexity, packaging costs, and waste, while also decreasing assay efficiency and throughput, as individual reagents may not be stable when combined.
Innovation Solution
A system comprising substrates with partitions and a pierceable seal allows for the separate storage of reagents, which can be aligned and sealed to maintain separation, and then mixed by applying a force to the seal, enabling efficient preparation and use of reagents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Device complexity
If multiple reagents are stored together in a single container, then packaging complexity and manufacturing costs are reduced, but reagent stability deteriorates due to incompatibility between reagents
Solution Approach 1:
The storage system is divided into multiple separate compartments within a single container, allowing incompatible reagents to be stored in different sections. This segmentation maintains reagent stability while avoiding the need for multiple separate packages, thus resolving the contradiction between packaging complexity and reagent stability.
2Stability of the object's composition
If multiple reagents are stored separately in multiple packages, then reagent stability is maintained, but manufacturing complexity and packaging costs increase
Solution Approach 1:
Multiple separate reagent packages are merged into a single integrated storage container with multiple compartments. This combining approach maintains reagent stability through physical separation while reducing packaging complexity and manufacturing costs by using one unified package instead of multiple separate ones.
3Stability of the object's composition
If multiple reagents are provided in multiple packages, then reagent stability is preserved, but assay efficiency and throughput decrease due to complex fluidics requirements
Solution Approach 1:
The reagent storage is segmented into distinct compartments within a single package, allowing automated fluid handling systems to access and mix reagents more efficiently. This segmentation maintains stability while improving assay throughput by simplifying the fluidics architecture compared to handling multiple separate packages.
4Quantity of substance
If multiple reagents are stored together, then packaging costs are reduced, but reagent activity and efficacy are reduced due to instability
Solution Approach 1:
The storage container is segmented into multiple isolated compartments, enabling cost-effective single-package packaging while preventing reagent instability. Each compartment maintains reagent integrity, ensuring reliability and efficacy, thus resolving the contradiction between packaging efficiency and reagent efficacy.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach stabilizes reagents during storage, reduces manufacturing and packaging complexities, and enhances assay efficiency and throughput by allowing for efficient reagent preparation and use.
Implementation Method 1
a seal disposed between the first substrate and the second substrate, wherein the seal is configured (i) to seal an interface between the first partition or the second partition to maintain the first reagent separate from the second reagent and (ii) to be pierceable upon application of a force
Data Source
AI summary
The present disclosure provides systems and methods for reagent storage. System may include one or more substrates comprising a partition. The partition may be configured to retain a first reagent separate from a second reagent. The partition may include a seal disposed between the first and second reagent. The seal may be configured to maintain the first reagent separate from the second reagent. The first and second reagent may be disposed in a first layer and a second layer, respectively, of frozen material. The first layer and second layer of frozen material may maintain the first reagent separate from the second reagent.