RebD Liquid Composition Using Mixed Solvents for High Solubility

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Solution Overview

Problem

Steviol glycosides, particularly rebaudioside D (RebD), have low solubility in water, limiting their use in beverages and concentrates, and existing methods do not effectively address this issue.

Innovation Solution

A liquid composition is developed using a mixed solvent of specific polyhydric alcohols, such as glycerin and ethanol, to enhance the solubility of RebD, allowing for a high concentration of RebD to be dissolved and maintained.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If water is used as solvent for RebD, then the beverage can be produced with simple composition, but the solubility of RebD is low

Engineering Contradiction:
Improvesolubility of RebDVSAvoidcomposition complexity
Core Design Contradiction:
Quantity of substanceVSDevice complexity

Solution Approach 1:

The patent uses a composite solvent system comprising multiple polyhydric alcohols (glycerin, ethylene glycol, propylene glycol) and ethanol in specific ratios instead of pure water. This composite solvent composition enables high solubility of RebD ( achieving more than 10 wt% dissolution) while maintaining manageable physical properties of the final beverage composition.

Inventive Principle:
Principle #40Composite materials

2Quantity of substance

If high concentration of RebD is achieved using existing methods, then the sweetness intensity is improved, but the viscosity increases and handleability deteriorates

Engineering Contradiction:
Improveconcentration of RebDVSAvoidhandleability
Core Design Contradiction:
Quantity of substanceVSEase of operation

Solution Approach 1:

The patent optimizes the ratio parameters of polyhydric alcohols to ethanol in the solvent system. Specifically, it uses polyhydric alcohols at 5-50 wt% and ethanol at 50-95 wt% in the mixed solvent, which allows achieving high RebD concentration (more than 10 wt%) while controlling the viscosity and maintaining good handleability of the liquid composition.

Inventive Principle:
Principle #35Parameter changes

3Quantity of substance

If more polyhydric alcohol is added to increase RebD solubility, then the solubility is improved, but the viscosity of the liquid composition increases

Engineering Contradiction:
Improvesolubility of RebDVSAvoidviscosity
Core Design Contradiction:
Quantity of substanceVSStress or pressure

Solution Approach 1:

The patent precisely controls the concentration parameter of polyhydric alcohols in the mixed solvent at 5-50 wt%, balancing solubility enhancement with viscosity control. By combining polyhydric alcohols with ethanol in this specific ratio range, the system achieves high RebD solubility while keeping the liquid composition sufficiently fluid for practical handling and beverage production.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution results in a liquid composition with improved handleability and higher RebD concentration, enabling the production of a beverage concentrate with enhanced solubility and reduced viscosity, facilitating efficient and rapid production.

Implementation Method 1

preparing a RebD-containing liquid composition using a mixed solvent containing a specific polyhydric alcohol and ethanol increases the solubility of RebD

Methodology Applied
Scientific EffectSolubility enhancement through mixed solvent system: Solvation

Implementation Method 2

a liquid composition containing RebD at high concentration can be obtained

Methodology Applied
Scientific EffectMolecular solvation: Solvation

Data Source

PatentEP4652855A1Rebaudioside d-containing composition
Publication Date: 2025.11.26 SUNTORY HLDG LTD
  • EP4652855A1 patent drawingFigure 1
  • EP4652855A1 patent drawingFigure 2
  • EP4652855A1 patent drawingFigure 3

AI summary

The development of a new method for improving steviol glycoside solubility is expected. According to an aspect of the present invention, provided is a liquid composition comprising: a mixed solvent containing 50-95 wt% of at least one polyhydric alcohol selected from the group consisting of glycerin, ethylene glycol, and propylene glycol and 5-50 wt% of ethanol on the basis of the total weight of the mixed solvent; and RebD, wherein the content of RebD is 1.5-30 wt% on the basis of the total weight of the liquid composition.