Reciprocating Mixing Device for Controlled Iodized Oil Emulsification
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Solution Overview
Problem
Conventional methods for preparing iodized oil emulsions for transcatheter arterial chemoembolization (TACE) suffer from poor emulsification effects, affecting treatment efficacy in patients with Barcelona Clinic Liver Cancer (BCLC) stage B.
Innovation Solution
A mixing device with clamping assemblies and a driving assembly that facilitates the reciprocal flow of liquids between containers to achieve a predetermined degree of mixing, forming a third liquid with improved emulsification.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional preparation methods are used to mix iodized oil and anticancer drug solution, then the preparation process is simple, but the emulsification effect is poor
Solution Approach 1:
The patent employs dynamic reciprocating motion of pistons to drive liquids back and forth between containers, transforming static mixing into a dynamic process that enhances emulsification effectiveness while maintaining manageable device complexity
Solution Approach 2:
The mixing device utilizes periodic reciprocating motion where liquids are repeatedly pumped back and forth between containers through controlled piston movements, creating continuous cyclic mixing action that significantly improves emulsification effect compared to conventional static mixing methods
2Stability of the object's composition
If manual mixing methods are used, then the device structure is simple, but the mixing uniformity is insufficient
Solution Approach 1:
The system transforms manual static mixing into a controlled dynamic reciprocating process, where pistons driven by a motor create consistent back-and-forth liquid flow between containers, ensuring uniform mixing and stable emulsion composition that manual methods cannot achieve
Solution Approach 2:
The control system monitors and regulates piston movement to maintain consistent reciprocating flow rates and timing, ensuring that mixing uniformity is preserved throughout the emulsification process through controlled feedback mechanisms
3Productivity
If rapid mixing is performed, then the mixing speed is fast, but the emulsification quality may be compromised
Solution Approach 1:
The system uses controlled periodic reciprocating motion at optimized frequencies to achieve both rapid mixing and high emulsion quality, where the cyclic back-and-forth flow pattern ensures thorough mixing without the detrimental effects of uncontrolled rapid agitation
Solution Approach 2:
The mixing device optimizes emulsion quality by precisely controlling parameters such as reciprocating speed, flow rate, and pumping frequency, adjusting these parameters to achieve the optimal balance between mixing speed and emulsion quality for specific iodized oil and drug formulations
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device ensures better emulsification of iodized oil emulsions, enhancing treatment effectiveness by controlling flow speed and pressure to achieve optimal physicochemical characteristics.
Implementation Method 1
driving, by a driving assembly of a mixing device, the first liquid and the second liquid to flow back and forth between the first container and the second container
Data Source
AI summary
The disclosure relates to a mixing device and a liquid mixing method. The mixing device comprises a first clamping assembly, a second clamping assembly and a driving assembly, the first clamping assembly is used for fixing a first container containing a first liquid, the second clamping assembly is used for fixing a second container containing a second liquid, the first container and the second container are in communication, the driving assembly drives the first liquid and the second liquid to flow back and forth between the first container and the second container to complete a predetermined degree of mixing to form a third liquid. The flow speed of the first liquid and the second liquid driven by the driving assembly is accurately controlled, so that an iodized oil emulsion with better physical and chemical characteristics is prepared, and an emulsion with better emulsifying effect and treatment effect is obtained.