Recombinant Gelatin Bone Regeneration Agent

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Solution Overview

Problem

Current bone regeneration therapeutic formulations rely on scaffolding materials that require additional physiologically active substances like BMP or PDGF for bone formation, and gelatin, despite being a denatured collagen product, has been shown to inhibit bone regeneration and lacks the necessary bone regeneration ability compared to collagen.

Innovation Solution

A recombinant gelatin with an amino acid sequence derived from a partial collagen sequence, specifically designed with Gly-X-Y repeats and cell adhesion signals, is used to promote bone regeneration independently without the need for additional bone regeneration agents.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If gelatin sponge is used as scaffolding material, then cost is reduced and ease of manufacture is improved, but bone regeneration ability deteriorates

Engineering Contradiction:

Improveease of manufactureVSAvoidbone regeneration ability

Core Design Contradiction:

Ease of manufactureVSReliability

Solution Approach 1:

The invention changes the chemical composition parameters of gelatin by incorporating specific amino acid sequences (Gly-X-Y repeats characteristic of collagen) and growth factors (BMP-2, PDGF) to transform gelatin from a material that inhibits bone regeneration to one that actively promotes it, while maintaining manufacturing simplicity

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The invention creates a composite material by combining gelatin with collagen-like amino acid sequences and bone growth factors, achieving both the ease of manufacture associated with gelatin and the bone regeneration ability of more complex materials

Inventive Principle:

Principle #40Composite materials

2Reliability

If collagen sponge is used as scaffolding material, then bone regeneration ability is improved, but cost increases and manufacturing complexity increases

Engineering Contradiction:

Improvebone regeneration abilityVSAvoidease of manufacture

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The invention copies the beneficial amino acid sequence structure of collagen (Gly-X-Y repeats) into gelatin, creating a simplified version that retains bone regeneration ability without requiring expensive collagen extraction and processing

Inventive Principle:

Principle #26Copying

3Reliability

If physiologically active substances like BMP or PDGF are added to scaffolding materials, then bone regeneration ability is improved, but cost increases significantly

Engineering Contradiction:

Improvebone regeneration abilityVSAvoidcost

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The invention makes gelatin multi-functional by combining its scaffolding function with bone regeneration function through the addition of growth factors, allowing a single material to replace multiple components (scaffolding + growth factor delivery system) and reduce overall treatment cost

Inventive Principle:

Principle #6Universality (Multi-functionality)

Data Source

PatentEP3391913B1A bone regeneration agent comprising gelatin

Publication Date: 2021.04.21 FUJIFILM CORP

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AI summary

It is an object of the present invention to provide a bone regeneration agent and a bone supplementation formulation, in which a supplementation material itself is capable of promoting bone regeneration. The present invention provides a bone regeneration agent which comprises a gelatin having an amino acid sequence derived from a partial amino acid of collagen.