Reconstructed Skin Model for Sensitive Skin Screening
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Solution Overview
Problem
Sensitive skin syndrome is poorly understood, lacking clear diagnostic criteria and effective treatment options due to its subjective nature and unclear molecular and cellular mechanisms, with existing methods failing to objectively differentiate it from normal skin.
Innovation Solution
A reconstructed skin model that replicates the features of sensitive skin by inducing inflammation markers and altering barrier function through exposure to exogenous stressors like lactic acid, allowing for the study and evaluation of cosmetic or pharmacological formulations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If subjective self-assessment methods are used to identify sensitive skin, then diagnosis can be performed, but objective differentiation from normal skin is not achieved
Solution Approach 1:
The patent creates an in vitro reconstructed skin model that copies the structural and functional characteristics of sensitive skin. This model reproduces the compromised barrier function and inflammatory responses observed in sensitive skin patients, allowing objective study without relying on subjective patient assessments. The model serves as a physical copy that manifests the pathological features for direct observation and measurement.
2Adaptability or versatility
If conventional skin models are used, then basic skin structure is represented, but sensitive skin-specific features are not reproduced
Solution Approach 1:
The patent applies local quality by introducing specific modifications to the reconstructed skin model to create sensitive skin characteristics. The model incorporates altered barrier properties, increased permeability, and enhanced inflammatory marker expression in specific regions, rather than uniformly modifying the entire skin structure. This allows the model to maintain basic skin functionality while reproducing localized sensitive skin pathologies.
Solution Approach 2:
The patent employs parameter changes by modifying key physiological parameters of the reconstructed skin model. These include altering barrier function parameters (increased permeability), adjusting inflammatory marker expression levels, and changing structural organization parameters to match sensitive skin characteristics. These parameter modifications enable the model to reliably reproduce sensitive skin features while maintaining versatility for various research applications.
3Reliability
If exogenous stressors are applied to reconstructed skin, then sensitive skin features are induced, but the model complexity increases
Solution Approach 1:
The patent applies preliminary action by pre-treating the reconstructed skin model with exogenous stressors during the model preparation phase. Rather than requiring complex ongoing interventions, the stressors (such as chemical agents or physical treatments) are applied in advance to induce and stabilize the sensitive skin features. This preliminary induction simplifies subsequent experimental procedures while maintaining reliable sensitive skin characteristics.
Data Source
AI summary
The present invention relates to models of reconstructed sensitive skin reproducing the features of sensitive skin, as well as to processes for obtaining such models. The present invention further relates to in vitro processes for testing formulations or active ingredients for the prevention or treatment of sensitive skin.