Red Yeast Rice Extract Enhances Loricrin Production
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Solution Overview
Problem
Current skin moisturizing substances fail to effectively promote the expression of loricrin in keratinocytes, which is crucial for strengthening the skin barrier function and preventing water loss and skin aging.
Innovation Solution
A skin external composition containing a red yeast rice extract, which increases the production of loricrin in keratinocytes, thereby enhancing skin moisturization and barrier function.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional skin moisturizing substances are used, then skin moisturization is provided, but the expression of loricrin in keratinocytes is not effectively promoted, resulting in insufficient skin barrier strengthening
Solution Approach 1:
The patent changes the chemical composition parameter by introducing red yeast rice extract containing monacolin K, which specifically activates the pathway to increase loricrin expression in keratinocytes, thereby simultaneously improving both loricrin production and skin barrier function
Solution Approach 2:
The patent uses a composite active ingredient system combining red yeast rice extract with other skin-compatible components, creating a synergistic effect that enhances both loricrin expression and overall skin barrier integrity
2Quantity of substance
If loricrin expression is increased to strengthen skin barrier, then water retention is improved, but current substances fail to achieve sufficient effect
Solution Approach 1:
The patent identifies red yeast rice extract as an intermediary substance that mediates between external application and internal cellular response, specifically activating keratinocyte differentiation and loricrin production, which then enables effective water retention
Solution Approach 2:
The patent modifies the biochemical parameter by using red yeast rice extract that contains monacolin K, which specifically upregulates loricrin gene expression and protein synthesis in keratinocytes, leading to enhanced water binding capacity
Data Source
AI summary
Disclosed herein is a skin external composition containing a red yeast rice extract. More particularly, disclosed is a skin external composition containing a red yeast rice extract which can increase the production of loricrin in keratinocytes and to strengthen the skin barrier function, thereby exhibiting an excellent effect of improving skin moisturization.