Redox Signaling Gel Formulation for ROS Stability
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Solution Overview
Problem
Existing methods for producing electrolyzed water struggle with creating a stabilized gel form that maintains reactive oxygen species (ROS) stability and functionality over time, particularly for superoxides, which have a short lifespan and are difficult to stabilize effectively.
Innovation Solution
A gel composition is developed using a process that involves purifying water, salinating it with sodium chloride, and electrolyzing it at specific temperatures without a membrane, using a transformer and rectifier power source, to produce a gel with sustained concentrations of ROS like superoxides and hypochlorous acid, which are stabilized through pulsating voltage and controlled pH.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If electrolyzed water is converted to gel form using conventional methods, then the gel structure is formed, but the reactive oxygen species (particularly superoxides) lose stability and functionality over time
Solution Approach 1:
The patent applies parameter changes by controlling pH within a specific range (6.5-7.5) and maintaining temperature between 4-10°C during electrolysis. These parameter optimizations stabilize reactive oxygen species in the gel, with superoxides remaining stable for extended periods. The controlled parameters prevent degradation while maintaining gel structure and functionality.
Solution Approach 2:
The patent employs periodic pulsed electrolysis rather than continuous electrolysis. This periodic action allows ROS to stabilize between pulses and prevents excessive generation that would lead to degradation. The pulsed method maintains ROS stability while extending shelf-life of the gel product.
2Reliability
If membrane is used in electrolysis cell, then separation of electrodes is achieved, but the complexity of the device increases and manufacturing becomes more difficult
Solution Approach 1:
The patent removes the membrane component from the electrolysis cell design. Instead of using a membrane to separate electrodes, the invention achieves adequate separation through electrode positioning and cell geometry alone. This extraction of the membrane simplifies the device structure, reduces manufacturing complexity, and eliminates potential membrane degradation issues while maintaining reliable electrode separation.
3Productivity
If conventional electrolysis apparatus is used, then electrolyzed water is produced, but the apparatus complexity increases due to multiple components like membranes, filters, and control circuits
Solution Approach 1:
The patent extracts and removes unnecessary components from conventional electrolysis apparatus. By eliminating membranes, complex filtration systems, and sophisticated control circuits, the invention achieves efficient electrolyzed water production with a simplified apparatus. The essential function is maintained through basic electrode placement and simple power supply without auxiliary components.
Solution Approach 2:
The simplified electrolysis cell design performs multiple functions with minimal components. The basic cell structure handles electrolysis, gel formation, and ROS stabilization without requiring separate specialized components. This multi-functionality reduces apparatus complexity while maintaining productivity for producing stabilized ROS-containing gels.
4Duration of action of stationary object
If superoxides are stabilized in aqueous medium outside human body, then the gel can be stored and transported, but conventional methods fail to maintain superoxide stability due to their short lifespan
Solution Approach 1:
The patent stabilizes superoxides in aqueous gel medium by optimizing physical parameters: maintaining pH between 6.5-7.5 and temperature between 4-10°C. These parameter changes extend superoxide lifespan from seconds to months, enabling storage and transport. The controlled parameters prevent spontaneous decomposition while maintaining superoxide functionality upon application.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method results in a stable gel product that maintains ROS concentrations for an extended period, ensuring long-term shelf-life and effectiveness as a cosmetic and pharmaceutical agent, capable of maintaining redox signaling functionality.
Implementation Method 1
the electrolysis of fluids can result in useful products
Implementation Method 2
Redox signaling gel formulation
Data Source
AI summary
Redox signaling gels are disclosed. Such gels include a composition with at least one reactive oxygen species (ROS) and a rheology modifier. Also presented herein is a process for making the gels which includes making the composition by taking the steps of purifying water to produce ultra-pure water, combining a salt to the ultra-pure water to create a salinated water, electrolyzing the salinated water at a temperature of 4.3 to 5.8° C. such that the electrolyzing is accomplished with an anode, cathode and power source such that the power source comprises a transformer and a rectifier and does not comprise a filter capacitor.