Reduced Coenzyme Q10 Particulate Composition Oxidative Stability
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Solution Overview
Problem
Reduced coenzyme Q10 is prone to oxidation, making it challenging to maintain stability during processing and storage, especially in oxygen-rich environments, leading to quality issues and potential health risks from by-products like dehydroascorbic acid and oxalic acid.
Innovation Solution
A particulate composition comprising reduced coenzyme Q10 with a water-soluble excipient matrix, where the oil component is polydispersed and forms a domain with high sphericity, combined with surfactants and sugars, to enhance oxidative stability and oral absorbability, and a method involving packaging in a moisture-proof environment to prevent oxidation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If reduced coenzyme Q10 is used to improve oral absorbability, then oral absorbability is improved, but oxidative stability deteriorates
Solution Approach 1:
The patent uses ascorbyl palmitate as an intermediary substance that acts as a reducing agent to maintain reduced coenzyme Q10 in its reduced state while protecting it from oxidation. This mediator substance donates electrons to keep coenzyme Q10 reduced without being directly oxidized itself, thus resolving the contradiction between maintaining oral absorbability and preventing oxidation
Solution Approach 2:
The patent creates an inert environment by using ascorbyl palmitate to establish a reducing atmosphere around the reduced coenzyme Q10. This chemical environment prevents oxygen from oxidizing the reduced coenzyme Q10, effectively creating a protective zone that maintains stability while preserving the reduced form's high oral absorbability
2Stability of the object's composition
If oxidized coenzyme Q10 is used to improve oxidative stability, then oxidative stability is improved, but oral absorbability deteriorates
Solution Approach 1:
The patent applies preliminary action by pre-reducing coenzyme Q10 to its reduced form and immediately stabilizing it with ascorbyl palmitate before the oxidation can occur. This preliminary reduction and stabilization prevents the need to use oxidized coenzyme Q10, thus maintaining high oral absorbability while achieving oxidative stability through the reducing agent
3Stability of the object's composition
If reducing agents are added to prevent oxidation, then oxidative stability is improved, but harmful by-products are generated
Solution Approach 1:
The patent changes the parameter of the reducing agent from water-soluble forms (which generate harmful by-products like dehydroascorbic acid and oxalic acid) to a lipid-soluble form (ascorbyl palmitate). This parameter change in solubility allows the reducing agent to function in the lipid environment of coenzyme Q10 without generating harmful water-soluble by-products, thus maintaining oxidative stability while avoiding harmful contaminants
4Stability of the object's composition
If complex composition systems are used to stabilize reduced coenzyme Q10, then oxidative stability is improved, but device complexity increases
Solution Approach 1:
The patent extracts and uses only the essential component needed for stabilization - ascorbyl palmitate - rather than employing complex multi-component systems. By identifying and utilizing this single key reducing agent, the patent achieves oxidative stability while minimizing composition complexity, avoiding the need for multiple stabilizers, antioxidants, and complex formulation systems
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition maintains high oral absorbability and stability of reduced coenzyme Q10, preventing oxidation and ensuring safety by reducing the formation of harmful by-products, thus providing a stable and effective nutritional supplement.
Implementation Method 1
A particulate composition comprising an oil component (A), comprising reduced coenzyme Q10, and a matrix comprising a water-soluble excipient, wherein the oil component (A) is polydispersed forming a domain in the matrix
Implementation Method 2
wherein the water-soluble excipient is a water-soluble polymer, alone or in combination with at least one kind selected from the group consisting of surfactant (C), sugar and a yeast cell wall
Implementation Method 3
reduced coenzyme Q10 is easily oxidized by molecular oxygen into oxidized coenzyme Q10, and therefore, stabilization of reduced coenzyme Q10 is an important issue
Data Source
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AI summary
The present invention provides a particulate composition wherein an oil component containing reduced coenzyme Q10 is polydispersed forming a domain in a matrix containing a water-soluble excipient, which simultaneously shows high oxidative stability and high oral absorbability, a production method thereof, and a stabilizing method thereof. It also provides a food, food with nutrient function claims, food for specified health uses, dietary supplement, nutritional product, animal drug, drink, feed, pet food, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the like, which contain the composition.