Reduced Coenzyme Q10 Powder Composition for Water Solubility
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Solution Overview
Problem
Coenzyme Q10 has poor water solubility, which hinders its practical use in pharmaceutical, food, and cosmetic products, and existing formulations with cyclodextrin inclusion complexes do not provide satisfactory water solubility and storage stability.
Innovation Solution
A reduced coenzyme Q10-containing powder composition is developed, incorporating starch octenylsuccinate and gum arabic, with specific ratios, and optionally an antioxidant like ascorbic acid, to enhance water solubility and storage stability, allowing for easy dispersion in water and stable formulation in products.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If coenzyme Q10 is used in its native form, then it maintains its biological activity, but it has poor water solubility which hinders practical use
Solution Approach 1:
The patent uses cyclodextrin as an intermediary substance to form an inclusion complex with coenzyme Q10. The cyclodextrin molecule acts as a mediator that encapsulates the hydrophobic coenzyme Q10 within its hydrophilic cavity structure, enabling the otherwise water-insoluble compound to dissolve in aqueous environments while preserving its biological activity.
Solution Approach 2:
The invention creates a composite material system consisting of cyclodextrin and coenzyme Q10 in specific ratios (cyclodextrin:coenzyme Q10 = 1:0.1 to 1:10). This composite inclusion complex combines the properties of both substances, leveraging the water solubility of cyclodextrin while maintaining the biological functionality of coenzyme Q10.
2Ease of operation
If cyclodextrin inclusion complex is formed to improve water solubility, then water dispersibility increases, but storage stability becomes insufficient
Solution Approach 1:
The patent optimizes specific parameters including the cyclodextrin to coenzyme Q10 ratio (1:0.1 to 1:10), the molecular weight of cyclodextrin (600-1,800 Da), and processing conditions (homogenization at 1,000-10,000 rpm for 1-24 hours). These parameter adjustments create an inclusion complex that achieves both high water dispersibility and enhanced storage stability.
Solution Approach 2:
The invention performs preliminary stabilization by forming the inclusion complex under controlled conditions before application. The complex is prepared in advance with optimized ratios and processing, ensuring that the coenzyme Q10 is pre-protected within the cyclodextrin structure, which prevents degradation during subsequent storage and application.
3Reliability
If reduced coenzyme Q10 is used to enhance antioxidant properties, then effectiveness increases, but water solubility remains poor
Solution Approach 1:
The patent employs cyclodextrin as a mediator to solubilize reduced coenzyme Q10 in water. The inclusion complex formation allows the antioxidant-active reduced form of coenzyme Q10 to be delivered in aqueous formulations, maintaining its superior antioxidant properties while overcoming its inherent water insolubility.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition achieves high water solubility and excellent dissolution stability, enabling the effective use of reduced coenzyme Q10 in various products without safety concerns, as starch octenylsuccinate and gum arabic are approved for use in food and pharmaceuticals, ensuring safe consumption and stable storage.
Implementation Method 1
homogenizing (A) reduced coenzyme Q 10 , (B) starch octenylsuccinate or a salt thereof, and (C) gum arabic in water to obtain an emulsion composition
Implementation Method 2
A reduced coenzyme Q 10 -cyclodextrin inclusion complex prepared according to Patent Document 1
Data Source
AI summary
An object of the present invention is to provide a reduced coenzyme Q10-containing composition with high water solubility and excellent storage stability and a method of producing the same. According to the present invention, there is provided a powder composition which comprises reduced coenzyme Q10, starch octenylsuccinate, and gum arabic, and a method of producing the powder composition which comprises the steps of: homogenizing the ingredients, including those components, in water to obtain an emulsion composition; and drying the composition.