Reduced Coenzyme Q10 Fatigue Agent with Vitamin C Stabilization
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Solution Overview
Problem
Current fatigue reduction agents are not suitable for long-term use by middle-aged and older individuals, as they are often stimulants designed for young people, and there is a lack of evidence on the effectiveness of reduced coenzyme Q10 in reducing fatigue, which is readily oxidized and thus not evaluated for its usefulness.
Innovation Solution
A fatigue reducing agent containing reduced coenzyme Q10, either alone or in combination with oxidized coenzyme Q10, which is more effective in increasing plasma levels and providing antioxidant protection, particularly in muscles, thereby reducing fatigue and oxidative stress.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If reduced coenzyme Q10 is used as a fatigue reducing agent, then anti-fatigue effect is improved, but stability is worsened due to easy oxidation by air
Solution Approach 1:
Vitamin C acts as an intermediary substance that protects reduced coenzyme Q10 from oxidation by air. The vitamin C donates electrons to reduced coenzyme Q10 when it becomes oxidized, thereby regenerating the reduced form and maintaining its anti-fatigue effectiveness throughout the shelf life and upon administration.
Solution Approach 2:
The invention creates a protective chemical environment by combining reduced coenzyme Q10 with vitamin C, which forms a reducing atmosphere that prevents oxidation. This chemical inerting approach maintains the stability of reduced coenzyme Q10 without requiring physical isolation or special storage conditions.
2Productivity
If oxidized coenzyme Q10 is administered, then absorption is improved, but anti-fatigue effect is reduced compared to reduced coenzyme Q10
Solution Approach 1:
The invention changes the oxidation state parameter of coenzyme Q10 from oxidized to reduced form, while simultaneously adding vitamin C to maintain this reduced state. This parameter change enables the compound to exhibit superior anti-fatigue effects while the vitamin C ensures stability for adequate absorption.
Solution Approach 2:
The invention creates a composite composition of reduced coenzyme Q10 and vitamin C. This composite material combines the high anti-fatigue activity of reduced coenzyme Q10 with the stabilizing properties of vitamin C, achieving both effectiveness and stability simultaneously.
3Power
If stimulants are used for fatigue reduction, then energy boost is improved, but safety for long-term use is worsened
Solution Approach 1:
The invention replaces long-acting stimulants with a composition of reduced coenzyme Q10 and vitamin C that acts more gently but can be safely administered continuously over long periods. This approach prioritizes sustained safety over immediate powerful effects, suitable for middle-aged and older adults requiring long-term fatigue management.
Solution Approach 2:
The invention changes the mechanism of action from stimulant-based (central nervous system activation) to metabolic support-based (mitochondrial function enhancement). This parameter change in the mode of action provides sustained energy production without the safety concerns associated with long-term stimulant use.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The agent effectively increases muscle coenzyme Q levels, providing significant anti-fatigue effects and protecting against muscle damage, especially in middle-aged and older individuals, improving their physical fitness and health.
Implementation Method 1
Coenzyme Q10 is a physiological component present as a constitutive component of the electron transport system of the mitochondria in cells of living organisms and functions as a transport component of the electron transport system by repeating oxidation and reduction in the living organism.
Implementation Method 2
reduced coenzyme Q10 is readily oxidized by air
Implementation Method 3
vitamin C, which prevents oxidation by air of the reduced coenzyme Q10
Implementation Method 4
Coenzyme Q is known to show activities in energy production, membrane stabilization, and antioxidation
Data Source
AI summary
To maintain physical fitness and health of middle-aged and older persons living in the threshold of the aging society, the present invention provides a fatigue reducing agent which is highly effective for preventing and reducing fatigue, wherein the agent is made of a composition of substances that are very safe so that long-term administration is possible. A composition containing reduced coenzyme Q was found to be effective for preventing and reducing fatigue, including muscle fatigue. Since the fatigue reducing effect of the composition of the present invention is seen not only in young rats but also more pronounced in aged rats, the present invention can provide the fatigue reducing agent which is very useful, especially, for middle-aged and older persons as well as for young people.