Reduction Optics Assembly for High-Density DNA Microarray Synthesis
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
The widespread use of DNA microarray chips is limited by their high cost, primarily due to the relatively low number of features per chip, which needs to be increased to reduce the cost per feature for large-scale studies.
Innovation Solution
A device and method utilizing a reduction optics assembly and a target assembly to synthesize ultra-high density DNA microarrays by projecting a pattern of light and dark areas onto a substrate, with precision movement stages to align and image the pattern, increasing feature density by reducing image size and enhancing chip throughput.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If the number of features per chip is increased to reduce cost per feature, then the cost per feature decreases, but the manufacturing precision and alignment difficulty increase
Solution Approach 1:
The patent replaces traditional mechanical alignment systems with a reduction optics system that uses optical projection to define feature locations. The micromirror array projects patterns through reduction optics onto the substrate, eliminating the need for mechanical positioning of each feature and enabling high-density arrays through optical scaling rather than mechanical precision.
Solution Approach 2:
The patent introduces a reduction optics system as an intermediary between the micromirror array and the substrate. This intermediary system scales down the projected pattern by a factor of five, allowing the micromirror array to operate at a larger scale while achieving high feature density on the substrate through optical reduction rather than direct mechanical positioning.
2Quantity of substance
If the image size is reduced to increase feature density, then the feature density increases, but the alignment precision requirements become more stringent
Solution Approach 1:
The patent replaces mechanical positioning systems with an optical projection and reduction system. The reduction optics assembly projects patterns from the micromirror array onto the substrate at a reduced scale, using optical physics rather than mechanical precision to achieve high feature density. This substitution allows feature density to be controlled by optical magnification factors rather than mechanical alignment precision.
Solution Approach 2:
The patent changes the optical parameters of the system by introducing a reduction optics assembly with a five-fold reduction ratio. This parameter change in optical scaling allows the projected pattern to be smaller on the substrate while maintaining the same physical dimensions in the projection system, thereby increasing feature density without proportionally increasing alignment difficulty.
3Quantity of substance
If a reduction optics system is introduced to increase feature density, then the feature density increases, but the device complexity increases
Solution Approach 1:
The reduction optics system serves multiple functions simultaneously: it reduces the projected pattern size to increase feature density, maintains alignment between successive projections, and enables the micromirror array to operate at optimal dimensions. This multi-functionality justifies the added optical components by consolidating several requirements into a single integrated system.
Solution Approach 2:
The system creates reduced optical copies of the micromirror array patterns on the substrate. Rather than physically scaling down the micromirror array itself, the system optically copies and reduces the projected patterns, achieving high feature density through optical replication at reduced scale rather than physical miniaturization of components.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution significantly increases the density of features on DNA chips, thereby reducing fabrication costs and enhancing chip throughput, with a reduction in image size by a factor of five increasing density by a factor of twenty-five.
Implementation Method 1
a reduction optics assembly configured to receive a light array of selectable regions of light and dark areas, to reduce a size of the light array in two-dimensions, and to project a pattern of the light array on a target surface
Implementation Method 2
emitting a light array of selectable regions of light and dark areas from a light emitting object array; receiving the light array emitted from the light emitting object array at a first aspheric mirror; reflecting the received light array from the first aspheric mirror towards a second aspheric mirror
Implementation Method 3
receiving the reflected light array from the first aspheric mirror at the second aspheric mirror; reflecting the received reflected light array from the second aspheric mirror towards the substrate; imaging a pattern formed by the light array onto a synthesis region of the active surface of the substrate, wherein a size of the pattern formed by the light array is reduced in two-dimensions
Data Source
AI summary
A device and a method for synthesizing a microarray are provided. The device includes a reduction optics assembly and a target assembly. The reduction optics assembly is configured to receive a light array of selectable regions of light and dark areas, to reduce a size of the light array in two-dimensions, and to project a pattern of the light array on a target surface. The target assembly includes a first stage and a second stage. The first stage is configured to move the target surface in at least two directions in plane with the projected pattern with a first precision. The second stage is mounted to the first stage and is configured to move the target surface in the at least two directions in plane with the projected pattern with a second precision that is smaller than the first precision.


