Reflective Absorbance Measuring Device for Lateral Flow Analysis
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Solution Overview
Problem
Current diagnostic methods, such as RIA and ELISA, require complex processes and specialized equipment, making them unsuitable for small hospitals or home use, and often necessitate separate devices for immunochromatography and absorbance measurements, which can be inaccurate due to air layers and require additional sample volumes.
Innovation Solution
A device that integrates reflective absorbance measurement and lateral flow assay, allowing for convenient, accurate, and rapid analysis of biological samples using a single device with a light transmitting member and sample inlets to minimize sample volume and prevent air layer interference.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If transmitted light absorbance measurement is used, then absorbance can be measured, but air layers interfere with light passage and require large sample volumes
Solution Approach 1:
The patent inverts the traditional transmitted light measurement approach by using reflective absorbance measurement. Instead of measuring light passing through the sample from one side, the device measures light reflected from the sample surface, eliminating the need for light to pass through air layers and reducing sample volume requirements.
Solution Approach 2:
The patent transitions from a one-dimensional transmitted light path to a two-dimensional reflective measurement geometry. The light source and detector are positioned at an angle to the sample surface, creating a reflective measurement path that avoids air layer interference and enables accurate measurement with minimal sample volume.
2Measurement precision
If transmitted light absorbance measurement is used, then absorbance can be measured, but air layers cause unreliable results
Solution Approach 1:
The patent inverts the traditional transmitted light measurement approach by using reflective absorbance measurement. Instead of measuring light passing through the sample from one side, the device measures light reflected from the sample surface, eliminating the need for light to pass through air layers and reducing sample volume requirements.
3Adaptability or versatility
If separate devices are used for immunochromatography and absorbance measurement, then each function can be performed, but device complexity and arrangement difficulty increase
Solution Approach 1:
The patent combines immunochromatography and absorbance measurement functions into a single integrated device. The device includes a sample application area for immunochromatography and a reflective absorbance measurement area with light source and detector, allowing both assays to be performed in one device with proper optical arrangement.
Solution Approach 2:
The patent creates a universal device that performs multiple diagnostic functions. The single device can conduct both immunochromatography for qualitative/quantitative analyte detection and reflective absorbance measurement for concentration determination, eliminating the need for separate devices and simplifying the diagnostic workflow.
4Measurement precision
If conventional ELISA methods are used, then analyte concentration can be measured, but complex multi-step processes and specialized equipment are required
Solution Approach 1:
The patent combines immunochromatography and absorbance measurement functions into a single integrated device. The device includes a sample application area for immunochromatography and a reflective absorbance measurement area with light source and detector, allowing both assays to be performed in one device with proper optical arrangement.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The integrated device provides accurate, reliable, and reproducible results with reduced sample volume requirements and improved user convenience by combining reflective absorbance and lateral flow assay functions in one device, enhancing analysis efficiency and accuracy.
Implementation Method 1
a light transmitting member (127), the light transmitting member being positioned such that it is located perpendicular to the sample receiving part (111)
Implementation Method 2
the sample receiving part (111) is configured to reflect an incident light illuminated through the light transmitting member (127)
Implementation Method 3
an integrated device for both measuring reflective absorbance and performing lateral flow assay
Data Source
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AI summary
The present application relates to a reflective absorbance measuring device, to a lateral flow analysis device, and to an integral apparatus including the two devices and capable of performing lateral flow analysis and reflective absorbance measurement at the same time. The reflective absorbance measuring device of the present application comprises: a base member having a sample-receiving portion formed therein; and a cover member for covering the top of the base member, wherein the cover member includes a sample insert hole through which a sample is inserted into the sample-receiving portion, and has a structure in which a light-transmitting member is formed so as to be vertical to the sample-receiving portion. The integral apparatus of the present application includes said cover member and base member, which are formed so as to extend in one direction on the reflective absorbance measuring device, a second sample insert hole and a measuring device are formed on the cover member, and the base member has a structure in which a strip-receiving portion is formed and may additionally include a measuring device cover that can be detachably opened and closed. Not only can the devices of the present application more quickly, conveniently, and easily measure absorbance while maintaining a predetermined level of accuracy, the integral apparatus enables lateral flow analysis information and absorbance measurement information to be simultaneously measured, thereby providing convenience.