Regenerative Medical Material with Controlled Degradation
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Solution Overview
Problem
Biological active glasses used in regenerative medicine face issues such as slow degradation, pH instability, high energy consumption in production, and inability to form porous materials, limiting their effectiveness and applicability in tissue repair.
Innovation Solution
A regenerative medical material with a three-dimensional network structure, composed of inorganics and organics in a specific mass ratio, using soybean hull extract as a phosphorus precursor and sintered at a lower temperature, which allows for controlled degradation and improved biological compatibility.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional biological active glasses are used with melting quenching reaction at 1700-1900°C, then the material achieves good bondability with bones and soft tissues, but the energy consumption is high and manufacturing investment is over one billion
Solution Approach 1:
The patent changes the temperature parameter from traditional 1700-1900°C melting quenching to a lower temperature sol-gel process, fundamentally altering the preparation conditions to reduce energy consumption while maintaining material performance
Solution Approach 2:
The patent replaces the high-temperature melting quenching mechanical process with a chemical sol-gel process, substituting thermal energy with chemical reactions to form the glass structure at lower temperatures
2Reliability
If traditional biological active glasses are used, then the material provides excellent osteoproductive or osteoconductive function, but the degradation rate is slow and complete degradation takes 1 to 2 years
Solution Approach 1:
The patent creates a composite material system combining inorganic biological active glass with organic components (collagen, chitosan, hyaluronic acid), where the organic phase accelerates degradation while the inorganic phase maintains osteoconductive function
Solution Approach 2:
The patent introduces a porous structure with controlled pore size and distribution, increasing surface area and facilitating fluid penetration, which accelerates degradation rate while maintaining structural support for tissue growth
3Reliability
If traditional biological active glasses are used, then the material forms a carbonate hydroxyapatite layer for tissue bonding, but the pH value becomes unstable and can reach 11, forming strong alkaline with cytotoxicity
Solution Approach 1:
The patent introduces organic components as intermediaries that buffer the pH during degradation, preventing extreme alkalinity while still allowing carbonate hydroxyapatite formation for tissue bonding
Solution Approach 2:
The patent modifies the chemical composition parameters by adding organic acids and buffers to the glass system, changing the pH profile during degradation from unstable high values to controlled physiological ranges
4Temperature
If traditional biological active glasses are used, then the material has amorphous two dimensional structure with low elastic modulus close to cortical bone, but the material cannot form porous structures, limiting compliance and extending functions
Solution Approach 1:
The patent transforms the dense amorphous structure into a porous three-dimensional network structure, maintaining the low elastic modulus characteristic close to cortical bone while enabling compliance and extended functional capabilities
Solution Approach 2:
The patent transitions from a two-dimensional amorphous structure to a three-dimensional porous network structure, adding spatial dimensionality that enables both mechanical compliance and enhanced biological functionality
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The material exhibits controlled degradation, enhanced biological compatibility, and porosity, facilitating tissue repair and drug loading, with improved physical and chemical properties compared to traditional biological active glasses.
Implementation Method 1
The inorganics is obtained through the sol-gelatin method
Implementation Method 2
The inorganics is obtained through the sol-gelatin method by adopting the soybean hull extract as the phosphorus precursor
Implementation Method 3
sintering at a constant temperature of 300∼700°C
Implementation Method 4
sintering at a constant temperature of 300∼700°C
Data Source
Figure 1
Figure 2
Figure 3a~3b
AI summary
Disclosed are a regenerative medical material for promoting the repair of soft and hard tissues, a preparation method therefor, and the use thereof. The regenerative medical material has a three-dimensional network structure and is a composite material composed of inorganics and organics, wherein the mass ratio of the inorganics to the organics is 2:1-4:1. Based on the total mass of the inorganics, the inorganics contain 12-38% SiO2, 3-5% Na2O, 15-29% CaO, 10-32.5% P2O5, 1-5% inositol hexaphosphate, 1-5% cyclohexanhexol phosphate, and the balance of impurities, with the content of impurities being less than 0.5%. Based on the total mass of the organics, the organics contain 30-60% carboxymethyl chitosan and 30-60% sodium hyaluronate. The regenerative medical material has a composition and properties better suited to the human body and plays a key role in cell repair and bonding, cell proliferation, and promoting the growth of hair follicles.