Remote Aspiration Pattern Control for Adaptive Thrombectomy Suction

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Solution Overview

Problem

Current thrombectomy devices are inadequate for effectively removing blood clots and debris from varying blood vessel diameters and are often harsh on fragile vessel walls, lacking flexibility and precision in tortuous vessels, and requiring multiple devices for complete clot removal.

Innovation Solution

A textile structure-based mechanical thrombectomy device with self-expanding bulbs and varying pore sizes, radiopaque patterns for visibility, and a hypotube with kerf patterns for flexibility, allowing for torsional rasping and single-device use across different vessel diameters without embolic protection or balloon inflation.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Object-affected harmful factors

If current thrombectomy devices are used to remove blood clots, then clot removal function is provided, but vessel wall trauma increases and flexibility in tortuous vessels decreases

Engineering Contradiction:

Improvevessel wall traumaVSAvoidflexibility in tortuous vessels

Core Design Contradiction:

Object-affected harmful factorsVSEase of operation

Solution Approach 1:

The device is divided into multiple self-expanding bulbs with varying pore sizes along the longitudinal axis, each segment serving specific functions for different clot types and vessel diameters, reducing overall trauma while maintaining flexibility

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

Different bulbs have different pore sizes and expansion characteristics tailored to specific locations along the device, allowing selective filtering and adaptation to varying vessel diameters and clot compositions without compromising overall device flexibility

Inventive Principle:

Principle #3Local quality

2Productivity

If multiple devices are used for complete clot removal, then clot removal completeness improves, but device complexity and procedure time increase

Engineering Contradiction:

Improveclot removal completenessVSAvoidnumber of devices required

Core Design Contradiction:

ProductivityVSDevice complexity

Solution Approach 1:

The device combines multiple functions in a single structure: self-expansion for navigation, variable pore sizes for selective filtering of different clot types, and longitudinal crowding capability for emboli prevention, eliminating the need for multiple specialized devices

Inventive Principle:

Principle #6Universality (Multi-functionality)

Solution Approach 2:

Multiple functional elements (bulbs with different pore sizes, hypotube with kerf patterns, radiopaque markers) are merged into a single integrated device that can handle various clot removal scenarios without requiring device changes

Inventive Principle:

Principle #5Merging (Combining)

3Ease of operation

If device profile is reduced for better navigation, then flexibility in small vessels improves, but structural strength for effective thrombectomy decreases

Engineering Contradiction:

Improvenavigation in small vesselsVSAvoidstructural strength for thrombectomy

Core Design Contradiction:

Ease of operationVSStrength

Solution Approach 1:

The device features a nested structure with self-expanding bulbs contained within a hypotube with kerf patterns, allowing compact delivery profile for navigation while providing structural strength when expanded for thrombectomy

Inventive Principle:

Principle #7Nested doll (Nesting)

Solution Approach 2:

The device combines different materials with complementary properties: the hypotube provides structural support with kerf patterns for flexibility, while the textile structure bulbs provide filtering capability and controlled expansion, achieving both low profile and high strength

Inventive Principle:

Principle #40Composite materials

Data Source

PatentUS20220313288A1Systems for remotely controlling aspiration patterns

Publication Date: 2022.10.06 INSERA THERAPEUTICS INC

AI summary

An aspiration system includes a pump and a control system in communication with the pump. The control system includes a microcontroller, an antenna configured to receive a signal, and a pump control board in communication with the microcontroller. The antenna is in communication with the microcontroller. Upon receiving the signal, the pump control board operates the pump to create negative pressure according to the signal.