Bias-Corrected Remote Biological Analyzer Verification
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Solution Overview
Problem
Current methods for controlling delocalized biological analysis devices are inadequate as they rely on approximate comparisons between capillary and venous blood measurements, leading to uncertainty and potential false readings, and require specific control solutions for each device type, making it difficult to ensure reliability and homogeneity across different devices.
Innovation Solution
An automated method that uses a control device to communicate with a central computer system to determine a bias based on qualitative data, allowing for continuous and homogeneous monitoring of delocalized analysis devices, accounting for environmental factors and consumable conditions, and providing a standardized comparison of results.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If control is performed by comparing capillary blood measurements with venous blood measurements, then delocalized analysis devices can be monitored, but measurement precision deteriorates due to inherent bias between blood types and analysis methods
Solution Approach 1:
The patent changes the reference parameter from venous blood measurements to manufacturer-provided control solutions with known target values. This eliminates the capillary-venous blood bias and creates a stable reference standard for comparing device measurements, thereby improving measurement precision while maintaining reliability.
2Measurement precision
If manufacturer-specific control solutions are used for each device type, then direct control is achieved, but device complexity increases and homogeneity across different devices cannot be ensured
Solution Approach 1:
The patent implements a universal control system where a single type of control solution can be used across multiple delocalized analysis device types. The central server manages device-specific parameters and bias corrections, allowing one control solution to serve multiple device types while maintaining measurement accuracy and ensuring homogeneity across the device fleet.
3Ease of operation
If approximate control methods are used, then ease of operation is maintained, but reliability deteriorates due to uncertainty in bias values
Solution Approach 1:
The system automatically performs bias determination and control assessments without requiring operator expertise in interpreting blood type biases. The delocalized device and central server handle the complex calculations and comparisons automatically, maintaining ease of operation while improving reliability through precise, automated bias correction.
Data Source
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AI summary
The invention relates to a method of controlling apparatus for delocalized biological analysis [i=10 to 14] intended to be implemented in situ from a so-called control apparatus [2]. According to the invention, this method comprises the steps of: a) inputting or receiving [E1] in situ qualitative data [QLD [i]] characterizing an apparatus for delocalized biology [i] that needs to be controlled and characterizing the environment in which this apparatus is situated, b) inputting or receiving [E0] the value [QTD[i]] of a biological variable of a so-called control solution [SC] measured by the delocalized biology apparatus [i] that is to be controlled, c) acquiring [E2] the value [QTD CTL] of the biological variable of the control solution [SC] measured by a reference biological analysis apparatus [3], d) transmitting [E3] the value [QTD[i]] input or received, the value [QTD CTL] acquired and qualitative data [QLD [i]] input or received to a centralizer computer system [4], e) determining [E4], within the centralizer computer system [4], an expected bias [B[i]] between the value [QTD] [i]] of the biological variable input or received and the value [QTD CTL] measured with the reference apparatus [3] as a function of the qualitative data [QLD [i]] input or received, including those apprising of the environment in which the apparatus is used, and comparison data [DC] stored in the computer system [4], f) comparing [E5] the value [QTD[i]] measured on the delocalized biology apparatus with the value [QTD CTL] measured by the reference apparatus [3] while taking account of the bias [B[i]], g) storing [E6] comparison data [DC] relating to the comparison performed in the computer system [4] and associated with qualitative data, h) formulating, within the computer system, a control report [C-R], i) sending [E7] the report [C-R] to the control apparatus [2,3´ ] or to a computer terminal associated with the control apparatus [2,3´ ].