Remote Neurostimulation Titration for Patient-State Therapy Adjustment
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Solution Overview
Problem
Existing neuromodulation therapies, such as deep brain stimulation (DBS), lack effective methods for personalized and remote adjustment of stimulation parameters to address individual patient needs and evolving medical conditions.
Innovation Solution
A system and method for remotely controlled in-home therapy titration that allows patients to customize stimulation settings using a user device, enabling modification of stimulation programs based on clinical response indicators under different patient states.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If traditional neuromodulation therapy is used with fixed stimulation parameters, then the treatment can be provided to patients, but it cannot be personalized or adjusted to address individual patient needs and evolving medical conditions
Solution Approach 1:
The patent segments the stimulation program into multiple electrode configurations and parameter sets that can be independently selected and adjusted. This allows the system to provide personalized therapy by enabling patients to switch between different pre-configured stimulation programs tailored to specific patient states or medical conditions, without requiring complex real-time optimization algorithms.
Solution Approach 2:
The system performs preliminary configuration of multiple stimulation programs with different electrode configurations and parameter values before patient use. These pre-configured programs are stored in the device memory, allowing patients to later select and adjust among them based on their current needs, thereby achieving personalization without requiring complex real-time computation.
2Adaptability or versatility
If stimulation parameters are fixed in the programming device, then the system is simple to operate, but it lacks the ability to be modified remotely or adjusted for different patient states
Solution Approach 1:
The patent implements a universal stimulation program structure that can serve multiple functions: it can be initially programmed by a clinician, later modified remotely via communication interfaces, and adjusted by patients themselves. The same hardware platform supports all these operations through standardized data structures and communication protocols, enabling remote adjustability without significantly complicating the basic operation for end users.
3Adaptability or versatility
If multiple electrode configurations and parameter values are stored for different patient states, then personalized therapy is enabled, but the data storage and processing requirements increase
Solution Approach 1:
The patent applies local quality by organizing stimulation programs with different electrode configurations and parameter values according to specific patient states or medical conditions. Each program is tailored to address particular therapeutic needs, allowing the system to store multiple specialized configurations rather than a single generic program, thereby enabling personalized therapy while efficiently managing storage through targeted, condition-specific data organization.
Data Source
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AI summary
Systems and methods for creating, maintaining, and remotely modifying stimulation settings for a neuromodulation therapy are discussed. An exemplary system includes an implantable stimulator to provide electrostimulation via a lead comprising a plurality of electrodes, and a programming device. The programing device identifies a search space of electrode configurations and parameter values for the lead, and determines, based on a clinical response indicator under a first patient state, at least one base stimulation setting including an optimal electrode configuration and an optimal stimulation parameter value from the identified search space. The system includes a remotely controlled therapy titration device that can modify the base stimulation setting under a second patient state based on an evaluation of a modified clinical response indicator. The modified base stimulation setting may be stored in the memory, or used by the implantable stimulator to deliver electrostimulation.