Remote PPG Signal Alignment for Tissue Perfusion Analysis

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Solution Overview

Problem

Existing PPG imaging technologies average perfusion differences across different tissue types, leading to degraded signal-to-noise ratio and inability to distinguish physiological from pathological perfusion changes, particularly in procedures like intestinal anastomosis.

Innovation Solution

A system and method for PPG analysis that processes images to determine PPG signals from different image regions, aligns them based on relative delays, and generates a global PPG signal with improved signal-to-noise ratio by synchronizing PPG signals using a reference signal.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Area of stationary object

If PPG signals from different image regions are averaged to generate a global PPG signal, then the coverage area is increased, but the signal-to-noise ratio is degraded due to time delays between signals from different regions

Engineering Contradiction:
Improvecoverage areaVSAvoidsignal-to-noise ratio
Core Design Contradiction:
Area of stationary objectVSMeasurement precision

Solution Approach 1:

The patent applies preliminary action by determining relative delays between PPG signals from different image regions before performing the averaging operation. The processor calculates time delays for each region relative to a reference region and pre-aligns the signals by compensating for these delays. This preliminary time alignment ensures that when signals are averaged to create the global PPG signal, they are synchronized in time, preventing destructive interference and maintaining high signal-to-noise ratio while still covering large tissue areas.

Inventive Principle:
Principle #10Preliminary action

2Quantity of substance

If PPG signals from different tissue types are averaged, then the overall perfusion measurement is obtained, but the ability to distinguish physiological from pathological perfusion changes is lost

Engineering Contradiction:
Improveoverall perfusion measurementVSAvoidperfusion difference information
Core Design Contradiction:
Quantity of substanceVSLoss of information

Solution Approach 1:

The patent applies segmentation by dividing the image into multiple regions of interest, each potentially containing different tissue types. For each region, a separate PPG signal is extracted and analyzed. The processor then determines relative delays for each region and performs time-aligned averaging only after regional analysis. This segmentation approach allows the system to maintain information about perfusion characteristics in different tissue regions while still producing an overall global PPG signal, thereby preventing loss of discriminatory information between physiological and pathological changes.

Inventive Principle:
Principle #1Segmentation

3Power

If PPG signals with different time delays are averaged, then the global PPG signal is generated, but destructive interference occurs reducing signal accuracy

Engineering Contradiction:
Improveglobal PPG signal strengthVSAvoidsignal accuracy
Core Design Contradiction:
PowerVSMeasurement precision

Solution Approach 1:

The patent applies parameter changes by dynamically adjusting the time alignment parameter for each regional PPG signal based on its relative delay. The processor calculates the time delay for each region relative to a reference region and applies a time shift parameter to compensate for this delay before averaging. This parameter adjustment ensures that all regional signals are synchronized to the same time reference, eliminating destructive interference that would otherwise occur when averaging signals with different phase relationships, thereby maintaining both signal strength and accuracy in the global PPG signal.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Enhances the accuracy of perfusion measurement by reducing destructive interference, allowing for precise identification of perfusion differences and improving the detection of inadequate healing in surgical procedures.

Implementation Method 1

PPG imaging utilizes an off-the-shelf camera and a light source to remotely detect the dynamic changes in blood volume beneath the skin and allows extracting blood pulsation signals

Methodology Applied
Scientific EffectPhotoplethysmography (PPG): Absorption (EM radiation)

Data Source

PatentEP4478938B1A system and method for tissue analysis using remote ppg
Publication Date: 2026.01.21 KONINKLIJKE PHILIPS NV
  • EP4478938B1 patent drawingFigure 1a~1b
  • EP4478938B1 patent drawingFigure 2~3
  • EP4478938B1 patent drawingFigure 4a~4b

AI summary

A system and method for PPG analysis processes images to determine PPG signals from different image regions of the images and determine relative delays between the PPG signals for the different image regions. The time alignment between the PPG signals is improved so that a more accurate global PPG signal is obtained for the overall region of interest. In this way, PPG signals are realigned or partially realigned to provide an overall PPG signal with improved signal to noise ratio.