Renal Denervation Effectiveness Measurement via Multi-Parameter Tracking
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Solution Overview
Problem
Current methods for assessing the effectiveness of renal denervation treatments lack comprehensive and real-time feedback, particularly in measuring physiological changes over time in the renal artery.
Innovation Solution
A method involving the insertion of a measurement device into an artery to track parameters such as arterial wall movement, blood flow rate, blood flow velocity, blood pressure, and arterial diameter over time, allowing for the assessment of treatment effectiveness by comparing pre- and post-denervation measurements.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If baseline and post-denervation measurements of renal nerve plexus electrical activity are performed and compared, then denervation effectiveness can be assessed, but the method lacks comprehensive real-time feedback on physiological changes over time
Solution Approach 1:
The patent implements continuous real-time monitoring of multiple physiological parameters (blood pressure, arterial diameter, wall movement, blood flow velocity) during and after denervation treatment. This feedback mechanism provides comprehensive information about physiological changes over time, allowing clinicians to assess treatment effectiveness dynamically rather than relying solely on baseline and post-denervation electrical activity comparisons.
Solution Approach 2:
The patent employs a single measurement device that simultaneously monitors multiple physiological parameters including blood pressure, arterial diameter, wall movement, and blood flow velocity. This multi-functional approach provides comprehensive assessment of denervation effectiveness across different physiological dimensions, rather than relying on a single measurement modality.
2Loss of information
If multiple parameters are tracked continuously during denervation treatment, then comprehensive real-time feedback is provided, but the device complexity increases
Solution Approach 1:
The patent utilizes a single measurement device capable of simultaneously monitoring multiple physiological parameters (blood pressure, arterial diameter, wall movement, blood flow velocity). This multi-functional device consolidates what would otherwise require multiple separate instruments, providing comprehensive physiological monitoring while minimizing the number of devices needed and reducing overall system complexity.
Solution Approach 2:
The patent combines multiple measurement capabilities (pressure sensing, dimensional measurement, motion detection, flow velocity assessment) into a single integrated measurement device. By merging these functions into one device rather than using separate instruments, the system reduces complexity while maintaining comprehensive monitoring capabilities.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach provides real-time and comprehensive feedback on the effectiveness of renal denervation treatments, enabling adjustments to the treatment profile and determining the need for repeat procedures based on measured parameters.
Implementation Method 1
a single measurement device adapted for emitting and receiving ultrasonic energy is used for treating and for measuring
Implementation Method 2
the device is adapted to measure renal artery wall movement using echo signals reflected by the artery wall
Implementation Method 3
the device is adapted to measure renal artery stiffness by calculating pulse wave velocity
Data Source
AI summary
The present invention, in some embodiments thereof, relates to methods and/or apparatus for measuring the effectiveness of a renal denervation treatment. In some embodiments, a method for determining effectiveness of the denervation treatment comprises tracking at least one of arterial wall movement, arterial blood flow rate, arterial blood flow velocity, blood pressure and arterial diameter at one or more selected locations in the renal artery over time, and assessing the effectiveness of said renal denervation treatment according to results obtained by tracking.