Renal Denervation Feedback via Nerve Activity Measurement
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Solution Overview
Problem
Current treatments for resistant hypertension, such as renal sympathetic denervation, lack precise feedback mechanisms to ensure complete denervation of renal nerves, leading to potential over-ablation or incomplete treatment.
Innovation Solution
A method and system for renal denervation validation and feedback that involves measuring renal nerve plexus electrical activity before and after denervation, using RF ablation or other techniques, to assess and adjust the denervation process, ensuring complete disruption of renal sympathetic nerves.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If renal sympathetic denervation is performed without precise feedback mechanisms, then the procedure can be performed, but complete denervation cannot be ensured leading to potential over-ablation or incomplete treatment
Solution Approach 1:
The patent implements a feedback mechanism where neural activity is recorded before and after RF ablation to assess denervation completeness. The system compares baseline neural activity with post-ablation activity to determine whether complete denervation has been achieved, allowing real-time adjustment of the ablation procedure to ensure complete denervation without over-treatment
Solution Approach 2:
The patent replaces subjective visual assessment of denervation with objective electrical measurement systems. By using neural activity recording and analysis to substitute for mechanical/visual inspection, the system achieves precise quantification of denervation completeness without requiring complex mechanical feedback devices
2Manufacturing precision
If RF energy delivery is not precisely controlled, then the denervation procedure can be completed quickly, but excessive denervation or incomplete treatment occurs
Solution Approach 1:
The system uses real-time feedback from neural activity monitoring to control RF energy delivery. By continuously assessing neural activity during ablation and comparing it to baseline measurements, the system precisely controls the amount of RF energy delivered to achieve complete denervation while avoiding over-treatment, with the denervation assessment module providing objective criteria for procedure completion
Solution Approach 2:
The patent performs baseline neural activity measurements before initiating RF ablation. These preliminary measurements establish a reference for complete denervation and allow the system to pre-determine the appropriate RF energy dosage needed to achieve complete denervation, thereby optimizing procedure time and energy delivery precision
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach allows for precise titration of RF energy delivery, preventing excessive denervation and ensuring adequate disruption of renal nerves, thereby improving treatment efficacy and response rates for resistant hypertension.
Implementation Method 1
Energy is delivered via a catheter to ablate the renal nerves in the right and left renal arteries
Implementation Method 2
RF energy delivery to ablate the renal nerves
Implementation Method 3
measuring renal nerve plexus activity by recording electrical activity from the renal nerve plexus
Data Source
AI summary
A renal denervation feedback method is described that performs a baseline measurement of renal nerve plexus electrical activity at a renal vessel; denervates at least some tissue proximate the renal vessel after performing the baseline measurement; performs a post-denervation measurement of renal nerve plexus electrical activity at the renal vessel, after the denervating; and assesses denervation of the renal vessel based on a comparison of the baseline measurement and the post-denervation measurement of renal nerve plexus electrical activity at the renal vessel.