Renal Denervation via Local pH Modulation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current methods fail to effectively modulate local tissue physiology to enhance drug uptake and therapeutic efficacy in targeted tissues, particularly for treating conditions like hypertension and heart failure, by altering pH and osmolarity around nerves.
Innovation Solution
A pharmaceutical preparation comprising guanethidine monosulfate or hemisulfate, delivered in a liquid, gel, or semisolid form, is administered to modulate local tissue pH and osmolarity, using ethanol and alkaline buffers to create a therapeutic environment that enhances cellular uptake and efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional drug delivery methods are used, then drug administration is simple, but cellular uptake and therapeutic efficacy are insufficient
Solution Approach 1:
The patent changes the pH parameter of the delivery vehicle to alkaline conditions (pH 8-11), which alters membrane permeability and polarization of the pharmaceutical agent, thereby enhancing cellular uptake and therapeutic efficacy without requiring complex delivery devices
Solution Approach 2:
The patent creates a localized alkaline environment at the target tissue site using pH-modulating compositions, which selectively enhances drug uptake in the intended region while maintaining normal physiological conditions elsewhere in the body
2Quantity of substance
If pH-modulating compositions are administered, then cellular uptake is enhanced, but tissue physiology is altered
Solution Approach 1:
The patent applies pH-modulating compositions before administering the pharmaceutical agent, preparing the target tissue by altering its pH and osmolarity to facilitate enhanced drug uptake, then allowing the tissue to return to normal physiology afterward
Solution Approach 2:
The patent uses pH-modulating compositions as intermediary agents that temporarily alter tissue conditions to enable enhanced drug delivery, after which the intermediary is removed or metabolized and tissue physiology returns to normal
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables more effective denervation of renal nerves, reducing blood pressure, improving heart failure symptoms, and treating insulin resistance and sleep apnea by optimizing drug delivery and tissue interaction.
Implementation Method 1
the preparation modulates local tonicity or osmolarity of the tissue to achieve enhanced cellular uptake of the pharmaceutical agent by said tissue
Implementation Method 2
the preparation modulates local tonicity or osmolarity of the tissue... wherein the liquid, gel, or semisolid comprises ethanol and the pharmaceutical agent comprises guanethidine monosulfate
Data Source
Figure 1A~1C
Figure 2A~2B
Figure 3
AI summary
Pharmaceutical preparations, compositions, systems, and devices including medical devices and diagnostic or therapeutic agents, and methods to treat disease by modification of local tissue environment to modulate the therapeutic index of locally or systemically delivered therapeutic or diagnostic agents. Improved ability to reduce sysmpathetic nerve activity in the adventitia and perivascular tissues around arteries and veins in the body. Modulation of the local tissue environment around an artery to enable more effective denervation with or without a therapeutic agent. Modulation may include adjustment of the pH of the tissue.