Renal Denervation Sensor Correlating Temperature and Impedance to Vasomotion
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Solution Overview
Problem
Current renal denervation procedures lack a practical and safe method to determine the successful completion of the treatment, relying on empirical manufacturer recommendations, which can lead to uncertainty and potential overtreatment.
Innovation Solution
A therapeutic assembly equipped with sensors to detect temperature and impedance changes within a vessel, correlating these parameters with blood flow and arterial pressure to determine renal arteriolar vasomotion, allowing for real-time assessment of treatment efficacy and automatic termination of the procedure.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If empirical manufacturer recommendations are used to determine treatment completion, then the procedure is simple to operate, but the measurement precision and reliability of treatment completion determination are insufficient
Solution Approach 1:
The system implements real-time feedback by continuously monitoring temperature and impedance parameters during renal denervation and automatically determining treatment completion based on predefined criteria. The processor analyzes the relationship between temperature rise rate and impedance change rate to provide objective feedback on treatment efficacy, eliminating reliance on empirical manufacturer recommendations and enabling precise, data-driven treatment termination decisions.
2Reliability
If real-time monitoring of temperature and impedance is implemented, then the reliability of treatment completion determination is improved, but the device complexity increases
Solution Approach 1:
The system employs multi-functionality by using a single integrated sensor that simultaneously measures both temperature and impedance parameters during renal denervation. The processor performs multiple functions including real-time data acquisition, correlation analysis between temperature and impedance changes, determination of treatment completion, and provision of visual/audio feedback. This multi-functional approach enhances reliability while minimizing device complexity by consolidating multiple monitoring functions into one unified system.
3Manufacturing precision
If automatic termination based on vasomotion assessment is implemented, then the safety and precision of renal denervation are improved, but the ease of operation decreases
Solution Approach 1:
The system implements self-service by automatically determining treatment completion and providing termination recommendations based on real-time analysis of temperature and impedance correlations. The processor autonomously assesses vasomotion changes, evaluates treatment efficacy against predefined criteria, and guides the operator on when to terminate the procedure. This self-service capability maintains high precision in renal denervation while simplifying operator workload by automating complex decision-making processes.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate and safe determination of treatment completion, reducing the risk of overtreatment and improving the precision of renal denervation by correlating temperature and impedance changes with blood flow and pressure, thus ensuring effective neuromodulation.
Implementation Method 1
a sensor configured to detect a temperature or an impedance at a location within a vessel over a period of time
Implementation Method 2
a sensor configured to detect a temperature or an impedance at a location within a vessel over a period of time
Implementation Method 3
The renal denervation device may deliver neuromodulation energy, such as radiofrequency (RF) energy, through the one or more energy delivery elements to the treatment site, which heats the wall of the vessel
Data Source
AI summary
Methods, systems, devices, assemblies and apparatuses for renal denervation. The therapeutic assembly includes a sensor configured to detect a temperature or an impedance at a location within a vessel over a period of time. The therapeutic assembly includes a processor coupled to the sensor. The processor is configured to correlate the temperature or the impedance to a flow of blood within the vessel or an arterial pressure of the blood within the vessel. The processor is configured to determine vasomotion of a wall of a distal vessel based on the flow of blood or the arterial pressure of the blood.