Renal Electroporation Bipolar Electrode System for Hypertension
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Solution Overview
Problem
Current methods for treating hypertension and syncope related to autonomic dysregulation are limited in effectively targeting the renal area without causing damage to blood vessels or coagulum formation, which can lead to complications.
Innovation Solution
A system and method for renal electroporation using bipolar electrodes that generate stimulation electrical currents, detect physiological responses, and adjust electrode configurations to minimize vessel damage and coagulum risk, allowing for extended electroporation without burning blood vessels.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If electrical energy is delivered to the renal area using conventional methods, then hypertension treatment is achieved, but blood vessel damage and coagulum formation occur
Solution Approach 1:
The patent changes the electrical parameters by using bipolar electroporation with specific pulse configurations (high voltage, short duration pulses) that enable effective nerve modulation while minimizing thermal damage to blood vessels. The parameter optimization includes controlling pulse width, frequency, and amplitude to achieve therapeutic effects without causing coagulum formation.
Solution Approach 2:
The patent replaces conventional monopolar electrical stimulation with a bipolar electroporation system that uses two electrodes positioned close together in the renal area. This substitution creates a more focused electric field that reduces spread to surrounding tissues and minimizes blood vessel damage while maintaining treatment effectiveness.
2Productivity
If high energy is delivered to achieve effective electroporation, then treatment efficacy is improved, but surrounding tissue architecture is altered
Solution Approach 1:
The patent applies local quality by concentrating the electroporation energy precisely at the target neural structures in the renal area while preserving surrounding tissue architecture. The bipolar electrode configuration creates a localized electric field that affects only the intended tissue, leaving blood vessels and other structures intact.
Solution Approach 2:
The patent uses dynamic pulse delivery with varying amplitude and duration to achieve effective electroporation while monitoring and preserving tissue architecture. The system adapts pulse parameters in real-time to maintain therapeutic efficacy without causing excessive tissue damage or altering tissue structure.
3Reliability
If conventional electrical stimulation is used, then neural modulation is achieved, but coagulum formation occurs leading to complications
Solution Approach 1:
The patent employs periodic electroporation pulses with specific frequency and duty cycle that enable effective neural modulation while allowing tissue recovery between pulses. This periodic action prevents continuous heating and reduces the risk of coagulum formation that occurs with conventional continuous or high-duty-cycle stimulation.
Solution Approach 2:
The bipolar electrode configuration acts as an intermediary that delivers electrical energy through a controlled pathway, focusing the electric field between the two electrodes and minimizing interaction with blood vessels. This intermediary approach prevents direct energy deposition into blood vessels, reducing coagulum formation risk.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The approach provides effective energy delivery to the renal area without altering surrounding tissue architecture, minimizing the risk of coagulum formation and enabling long-term electrode placement, thus effectively treating hypertension and reducing the risk of complications.
Implementation Method 1
The instructions can cause the processor to generate, via the pulse generator, a stimulation electrical current to cause stimulation between the first electrode and the second electrode, detect, via the sensor, a physiological response to the stimulation electrical current
Implementation Method 2
when the physiological response is detected, generate an electroporation electrical current to cause electroporation between the first electrode and the second electrode
Data Source
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AI summary
This document describes methods and materials for improving treatment of hypertension. For example, this document describes methods and devices for electroporation of nerves in the renal area to treat hypertension.