Renal Flow Modifiers for Transrenal Pressure Gradient
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Solution Overview
Problem
Current therapies for cardiorenal syndrome (CRS) do not effectively address the specific need to improve renal function and spare renal injury without affecting other organ systems, as they either increase fluid status or hemodynamic status with off-target effects.
Innovation Solution
The use of flow modifiers, including microaxial pumps and passive wings or nozzles, configured to increase renal artery pressure and decrease renal vein pressure, creating a transrenal pressure gradient to enhance renal perfusion and function, with a controller to optimize flow based on real-time sensor data.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If current therapies increase fluid status or hemodynamic status to improve renal function, then renal perfusion may be improved, but off-target effects occur affecting other organ systems
Solution Approach 1:
The therapy is segmented into two distinct flow modifiers: a first flow modifier positioned to increase renal artery pressure and a second flow modifier positioned to decrease renal vein pressure. This segmentation allows independent control of arterial inflow and venous outflow to the kidney, enabling targeted improvement of renal perfusion without affecting other organ systems through systemic hemodynamic changes.
Solution Approach 2:
The system applies local quality by creating a pressure gradient specifically across the renal vasculature. The first flow modifier increases pressure locally at the renal artery inlet, while the second flow modifier decreases pressure locally at the renal vein outlet, thereby concentrating the therapeutic effect specifically in the kidney region rather than systemically.
2Quantity of substance
If flow modifiers increase renal artery pressure to improve renal function, then glomerular filtration rate increases, but renal vein pressure may increase reducing the transrenal pressure gradient
Solution Approach 1:
The second flow modifier acts as a counterweight to the pressure increase generated by the first flow modifier. By actively decreasing renal vein pressure through the second flow modifier, the system counteracts the potential back-pressure effect that would otherwise reduce the transrenal pressure gradient, thereby maintaining optimal conditions for glomerular filtration.
Solution Approach 2:
The system performs preliminary action by pre-establishing the pressure gradient across the kidney before initiating full therapeutic flow. The coordinated action of increasing arterial pressure and decreasing venous pressure creates an optimized pressure gradient in advance, ensuring maximal glomerular filtration rate from the outset of therapy.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach improves renal function by increasing glomerular filtration rate (GFR) and diuresis, reduces renal injury, and alleviates congestion, thereby enhancing patient outcomes by directly targeting renal perfusion without off-target effects.
Implementation Method 1
Each flow modifier may be configured to increase a transrenal pressure gradient and/or improve renal perfusion
Data Source
AI summary
Systems and techniques for improving cardiorenal syndrome (CRS) may be provided. The systems may include a first flow enhancer configured to increase a renal artery pressure. The systems may include a second flow enhancer or flow restrictor configured to reduce a renal vein pressure. Each flow enhancer or flow restrictor may be configured to increase a transrenal pressure gradient, improve filtering and renal perfusion.