Renal Response Index Device for Hypertension Treatment Stratification
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Solution Overview
Problem
Current hypertension treatment procedures, particularly renal denervation, exhibit significant variability in patient response, making them cumbersome and inefficient.
Innovation Solution
A device and method for determining a renal response index by measuring physiological parameters under stimulated and non-stimulated conditions, calculating a ratio, and generating an index to assess suitability for renal denervation, facilitating more informed treatment decisions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If renal denervation is performed to treat hypertension, then blood pressure control is improved, but treatment response varies significantly between patients
Solution Approach 1:
The patent applies preliminary action by measuring physiological parameters (such as renal vascular resistance, blood flow, or pressure) before renal denervation treatment to predict patient response. This pre-treatment assessment allows clinicians to identify patients likely to respond well to renal denervation, thereby improving treatment reliability and reducing variability in outcomes across different patients.
2Measurement precision
If multiple measurements are taken under different conditions to improve prediction accuracy, then treatment selection is optimized, but measurement complexity increases
Solution Approach 1:
The patent applies local quality by focusing measurements on specific physiological parameters at specific locations in the renal vasculature under specific conditions (e.g., stimulated vs. non-stimulated states). Rather than conducting comprehensive systemic assessments, the invention targets localized renal physiological responses, thereby improving prediction accuracy while keeping the measurement protocol manageable and clinically feasible.
Data Source
AI summary
The present invention relates to determining a treatment response index. In order to improve and facilitate hypertension treatment procedures, a device (10) for determining a treatment response index is provided that comprises a data input (12), a data processor (14) and a data output (16). The data input is configured to receive a value (18) of at least one first measurement of a physiological parameter of a subject's vasculature under a first condition; and to provide a value (20) of at least one second measurement of the physiological parameter of the vasculature under a second condition. In the second condition, a pre-determined stimulation is provided, and the first condition is non-stimulated or at least differently stimulated. The data processor is configured to generate a treatment response index. In an example, the data output is configured to provide a classification of the subject into one of at least two groups of subjects, based on the treatment response index.