Repositionable Over-the-Scope Clip for Sealed Full Tissue Resection
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Solution Overview
Problem
Endoscopic procedures such as full thickness tissue resection and treatment of issues outside the GI tract can lead to intrabdominal hypertension and cancer cell seeding, and create tissue openings that need to be hygienically sealed.
Innovation Solution
A clipping system with a disc-shaped clip mounted over an endoscope, featuring cut-outs for fingers that move between open and closed configurations, controlled by extending members and control members, allowing precise clipping and repositioning, and a membrane to trap clipped tissue, preventing cancer seeding.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If full thickness tissue resection is performed to treat cancerous lesions, then complete removal of the lesion is achieved, but the risk of cancer cell seeding and intrabdominal hypertension increases
Solution Approach 1:
The patent applies preliminary action by deploying the clip across the full-thickness resection defect before removing the resected tissue specimen. This sequence prevents cancer cells from spilling into the peritoneal cavity during specimen extraction, as the defect is already sealed. The clip is positioned and secured in advance, creating a barrier that contains any potential cancer cell leakage during the subsequent tissue removal process.
Solution Approach 2:
The patent converts the potentially harmful full-thickness defect into a beneficial sealed opening. By intentionally creating a controlled full-thickness resection and then immediately sealing it with a clip, the procedure transforms what could be a source of cancer cell seeding into a controlled, sealed pathway that prevents seeding while allowing complete lesion removal.
2Reliability
If full thickness tissue resection is performed to treat cancerous lesions, then complete removal of the lesion is achieved, but tissue openings are created that require sealing
Solution Approach 1:
The patent applies universality by designing a clip that performs multiple functions: it seals the full-thickness resection defect to prevent cancer cell seeding and simultaneously provides structural support to the gastrointestinal wall. The self-expanding mechanism of the clip allows it to adapt to various defect sizes and locations, making it a universal solution for full-thickness resections throughout the GI tract.
3Object-affected harmful factors
If a clip is deployed to seal tissue openings, then cancer cell seeding is prevented, but the ability to reposition or adjust the clip is limited
Solution Approach 1:
The patent applies dynamics by designing a self-expanding clip that transitions from a compressed delivery configuration to an expanded deployed configuration. The clip remains flexible and adjustable during the deployment process, allowing the operator to reposition it along the insertion device before final release. Once deployed, the clip maintains its sealing function while the dynamic expansion mechanism ensures proper positioning.
4Manufacturing precision
If control members are used to move the clip between configurations, then precise clipping is achieved, but the device structure becomes more complex
Solution Approach 1:
The patent applies self-service by designing a self-expanding clip mechanism that uses the elastic properties of the clip material itself to provide the expanding force. The control members simply guide and release the clip rather than actively driving its expansion. This reduces the complexity of the control mechanism while maintaining precise positioning capability, as the clip's own structural properties provide the necessary expansion force.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The system effectively seals tissue openings and minimizes cancer seeding by allowing precise clipping and containment of resected tissue, optimizing endoscopic procedures.
Implementation Method 1
the clip movable between an insertion configuration, in which the fingers extending along an exterior surface of the end cap so that tips of the fingers are separated from one another in an open configuration, and an initial deployed configuration, in which the tips of the fingers revert toward a biased closed configuration
Data Source
AI summary
A clipping system includes a clip, extending and control members and an endcap mounted on an insertion device. A planar body of the clip includes first and second cut-outs defining fingers. The control members slide within extending members to releasably couple to the clip so that movement the control members moves the clip between an insertion configuration, an initial deployed configuration and a review configuration in which the end cap is withdrawn proximally away from the clip to enhance visual observation of the clip. The control member is operable to retract the clip proximally over the end cap toward the insertion configuration so that the fingers are forced open as the clip is retracted over the end cap, freeing the clip from tissue on which it had been clipped to reposition the clip if necessary.