Resilient Mesh Occlusion Device for Retrievable Aneurysm Sealing
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Solution Overview
Problem
Current occlusion devices for treating aneurysms, particularly neurovascular aneurysms, face challenges such as embolic material migration, irreversible occlusion of parent arteries, and the need for additional anchoring mechanisms, which can lead to complications like stroke and increased surgical trauma.
Innovation Solution
An occlusion device using a minimum amount of fully-retrievable, low-profile resilient mesh material that is oversized to conform to the aneurysm, eliminating the need for additional anchoring and minimizing clot emboli formation, with a marker to seal the aneurysm neck and promote clot formation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If additional anchoring mechanisms are used to secure the occlusion device, then device stability is improved, but device complexity and surgical trauma increase
Solution Approach 1:
The occlusion device utilizes the aneurysm's own geometry and blood flow dynamics to achieve anchoring. The oversized device conforming to the aneurysm walls creates mechanical friction and engagement without requiring separate anchoring components, allowing the device to secure itself within the aneurysm sac.
Solution Approach 2:
The invention removes the anchoring mechanisms from the device structure entirely, using only the mesh body that conforms to the aneurysm. By extracting the anchoring function from dedicated components and integrating it into the basic device structure, complexity is reduced while maintaining stability.
2Reliability
If more deployable material is used to ensure complete aneurysm occlusion, then occlusion effectiveness is improved, but the risk of clot emboli formation increases
Solution Approach 1:
The device is designed with non-uniform mesh density and varying strand thicknesses in different regions. Areas with higher clot formation needs have denser mesh configurations, while other areas use sparser structures to minimize emboli risk, creating locally optimized occlusion properties.
Solution Approach 2:
The invention varies physical parameters of the mesh material including strand diameter, mesh aperture size, and material composition across different portions of the device to balance occlusion effectiveness with reduced emboli generation, rather than using uniform material properties throughout.
3Reliability
If a larger occlusion device is used to seal the aneurysm neck effectively, then sealing effectiveness is improved, but device retrievability becomes more difficult
Solution Approach 1:
The device incorporates dynamic characteristics through its resilient mesh structure that can deform and contract. The mesh body can be compressed to a smaller delivery profile for easy retrieval through the catheter, then expands to the oversized configuration for effective sealing, allowing size transformation between deployment and retrieval phases.
Solution Approach 2:
The occlusion device uses a flexible mesh construction that can be collapsed into a thin, low-profile configuration for delivery and retrieval, then expands to form a large sealing surface. This flexible shell structure enables the device to achieve both large sealing area and easy retrievability through dimensional transformation.
4Reliability
If traditional occlusion devices are used, then anchoring capability is improved, but the need for anti-coagulation therapy increases due to clot emboli risk
Solution Approach 1:
The device converts the potentially harmful clot formation process into a beneficial anchoring mechanism. By allowing controlled clot formation within the mesh structure, the device achieves secure anchoring while the clots themselves become part of the sealing mechanism, reducing the need for anti-coagulation therapy.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device effectively seals the aneurysm neck, reduces the risk of clot emboli, and minimizes the need for anti-coagulation therapy, while being fully retrievable and adaptable to various aneurysm morphologies.
Implementation Method 1
low profile resilient mesh material which is oversized to conform to the aneurysm
Data Source
AI summary
Provided herein is an occlusion device for intrasaccular implantation and/or vascular occlusion comprising: (a) a substantially solid marker having a proximal end, and a distal end; and (b) a low profile resilient mesh body attached to the distal end of the marker, the body having a delivery shape and a deployed shape capable of conforming to aneurysm walls; wherein the body has a diameter greater than a diameter of an aneurysm to be treated. Also provided herein is a kit comprising the occlusion device disclosed herein and a means for delivery thereof. Methods of manufacture and use of the occlusion device disclosed herein are also disclosed.