Resin Composition for Transparent, Protein-Resistant Molded Articles
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Solution Overview
Problem
Existing polymer materials used in medical instruments and containers suffer from protein adhesion, leading to decreased detection sensitivity and reproducibility, and lack transparency required for certain applications.
Innovation Solution
A resin composition comprising thermoplastic polyurethane and an amphiphilic (meth)acrylic-based copolymer with a refractive index difference of 0.018 or less, and optionally containing structural units from aliphatic or alicyclic isocyanate compounds, to enhance protein adhesion suppression and transparency.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional polymer materials are used, then protein adhesion suppression is achieved, but transparency deteriorates
Solution Approach 1:
The patent controls the refractive index of the (meth)acrylic-based copolymer to be within a specific range (1.380-1.520) and ensures the difference in refractive index between the copolymer and thermoplastic polyurethane is 0.030 or less. This parameter control allows light to pass through the blended material without significant scattering, maintaining transparency while the amphiphilic structure of the copolymer suppresses protein adhesion.
Solution Approach 2:
The patent creates a composite material system by blending thermoplastic polyurethane with (meth)acrylic-based copolymer in specific ratios (5-50 mass%). The composite structure combines the biocompatibility and protein adhesion suppression properties of the amphiphilic copolymer with the mechanical properties and transparency of the thermoplastic polyurethane, achieving both requirements simultaneously.
2Reliability
If amphiphilic block copolymer is used to suppress protein adhesion, then protein adhesion suppression is improved, but transparency deteriorates
Solution Approach 1:
The patent specifically controls the refractive index parameter of the (meth)acrylic-based copolymer to be within 1.380-1.520, and ensures the refractive index difference with thermoplastic polyurethane is 0.030 or less. This precise parameter control resolves the transparency issue that previously occurred with amphiphilic block copolymers while maintaining protein adhesion suppression through the amphiphilic structure.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The resin composition achieves excellent protein adhesion suppression and transparency, making it suitable for medical components requiring antithrombotic properties and transparency.
Implementation Method 1
wherein the (meth)acrylic-based copolymer (B) is an amphiphilic copolymer
Implementation Method 2
a difference in a refractive index between the thermoplastic polyurethane (A1) and the (meth)acrylic-based copolymer (B) is 0.018 or less
Data Source
AI summary
The present disclosure relates to a resin composition containing: a thermoplastic polyurethane (A1) or a thermoplastic polyurethane (A2); and a (meth)acrylic-based copolymer (B), wherein the (meth)acrylic-based copolymer (B) is an amphiphilic copolymer, a difference in a refractive index between the thermoplastic polyurethane (A1) and the (meth)acrylic-based copolymer (B) is 0.018 or less, and the thermoplastic polyurethane (A2) contains a structural unit derived from at least one of an aliphatic isocyanate compound and an alicyclic isocyanate compound.